Nurses commonly experience long-term disbursing empathies that due to continuously expose to patients’ traumas or suffers. Accumulating with rigorous nursing works, they may develop negative emotions or even symptoms. This is called compassion fatigue. If nurses’ compassion fatigues are not appropriately adjusted, the quality of care will be affected and the nurses’ abilities of sympathy may be lost. The purpose of this study is to understand the current stats of compassion fatigue, compassion satisfaction, and burnout among female nurses. A retrospective cross-sectional quantitative research design was applied in this study using structured questionnaires in the data collection. A total of 357 participants from a medical center in the South Taiwan were recruited through purposive non-random sampling procedures. The data collection was from January 2014 to March 2014. The results of the study show that nurses’ compassion fatigues were belong to the extremely high-risk group, compassion satisfactions were belong to the high level satisfaction group, and burnouts were belong to the high-risk group. Compassion satisfactions and burnouts were significant different in marriage status. Married nurses had higher compassion satisfactions and burnouts than unmarried nurses. Compassion fatigues, compassion satisfactions, and burnouts were all significant different in the level of leisure. Moreover, compassion fatigues and burnouts were both significant different in terms of seniority, with the “Mesozoic” nurses had the highest level of compassion fatigues. All of compassion fatigues, compassion satisfactions, and burnouts were no differences in terms of religions, work divisions, and work time. Based on the results of the study, strategies to adjust nurses’ compassion fatigues in the education, administration, clinical practice, and research areas were proposed.