Objectives. The annual report of United States Renal Data System(USRDS, 2010) shows that the ranks of the incidence and prevalence of End Stage Renal Disease (ESRD) of Taiwan are the world third and first individually in 2008. The Chronic Kidney Disease(CKD) already just becomes “Taiwan new country sickness”. ESRD costs 3,500 million NT dollars for the dialysis treatment per year, and causes the serious burden on the national medical resources. The research objectives are to discussthe impact of CKD education on the hemodialysis medical resources, and provide suggestions for the CKD prevention in the future. Designs. Two-stage Quasi-experimental retrospective study design. The study includes before and after six months the date of the first time dialysis. The experimental group takes health education and the control group doesn’t. And the significance of medical utilization and the medical expense are tested through pair-t test. Data. Secondary data from someone hospital includes the medical record file with hemodialysis patients’ data in 2008-2009 and their NHI claim files. Subjects. Hemodialysis patient. The matching criteria are the demography factors, the disease factor and the class of chronic kidney disease. The demography factors are gender and age; the disease factor is diabetes; and the class of chronic kidney disease includes Stage 3-5. The experimental and control group has 32 patients each other. Results. 1.The medical resources, before the dialysis: (1) The medical utilization: For the renal outpatient visits, the experimental group with 142 visits is more than the control group with 102 visits (p<0.05). For inpatient admissions, the experimental group with 53 admissions is more than the control group with 45 admissions (p>0.05). (2) The medical expense: For the renal outpatient cost, the experimental group with 493,000 dallors is more than the control group with 228,000 dallors (p<0.05). For inpatient cost, the experimental group with 4,177,000 dallors is more than the control group with 2,687,000 dallors (p>0.05). 2. The medical resources, after the dialysis for six months : (1) The medical utilization: For the renal outpatient visits, the experimental group with 105 visits is more than the control group with 65 visits (p>0.05). For inpatient admissions, the experimental group with 21 admissions is less than the the control group with 26 admissions (p>0.05). (2) The medical expense: For the renal outpatient cost, the experimental group with 172,000 dallors is more than the control group with 169,000 dallors (p>0.05). For inpatient cost, the experimental group with 1,852,000 dallors is less than the control group with 2,264,000 dallors (p>0.05). 3. The medical resources, before the dialysis and after for six months : (1) The medical utilization: For the renal outpatient visits, the experimental group with 247 visits is more than the control group with 167 visits (p<0.05). For inpatient admissions, the experimental group with 74 admissions is more than the the control group with 71admissions (p>0.05). (2) The medical expense: For the renal outpatient cost, the experimental group with 665,000 dallors is more than the control group with 397,000 dallors (p<0.05). For inpatient cost, the experimental group with 6,029,000 dallors is more than the control group with 4,951,000 dallors (p>0.05). Conclusions. Before the dialysis, medical utilization and medical expense of patients with CKD health education are more than who without CKD health education,significantly. Before the dialysis and after for six months, medical utilization and medical expense of patients with CKD health education are more than who without CKD health education, too. As a whole, the patients with CKD health education does not reduced the total medical resources.