Background: As the standard of education and the level of general knowledge raise, the population has increasingly higher expectations of medical care and an individual’s rights. If an unexpected matter occurs during a medical procedure, it can easily turn into a medical malpractice dispute. Therefore, doctors have to think deeply about the importance of physician-patient relationship. Dale Camegie said about success ‘only 15 percent of people`s success could be attributed to skills and 85 percent of one`s success would be determined by what they call “ability to deal with people and attitude”.’ Furthermore, according to Cai Zonghong et al, the result of this shows that a physician-patient relationship is affected more by communication ability than professional ability. In recent years, the medical education has developed patient-centered and student- centered approaches. The research in the world has mostly started with the feelings of the patients rather than the feelings of the medical students. Therefore, this research emphasizes on the perspective of medical students. Goals: This research is based on the ‘Theory of Planned Behavior” to explored the correlation of behaviors, subjective standard, perceived behavioral control of the medical students to the intention of physician-patient communication of medical students. Therefore, it explored the correlation between the intention of physician-patient communication and the execution of this communication. Furthermore, it explored the different outcome for different grade medical students to physician-patient communication. Method: The present study was constructed using a cross-sectional questionnaire. Participants were recruited from fourth, sixth, and seventh grade medical students in a public university in the south of Taiwan. The data was collected by a structured questionnaire and purposive sampling which was aimed at medical college students who were doing Objective Structured Clinical Examination (OSCE). The effective questionnaires returned were 176, which was equal to 83％ of the total questionnaires. The effective samples were analyzed by SPSS 18.0 version and AMOS 18.0 software, and further examined the hypothesis through structure. Results: The results of the study showed: (1) there is a positive correlation between the physician-patient relationship and medical practice behavior safeguard and the physician-patient communication attitude. (2) There is also a positive correlation between Peer influence, higher authority influence and specialized ethics cognition to subjective standard. (3) A positive correlation was also found between the attitude of physician-patient communication, subjective standard and cognition behavior control and subjective standard. (4) There is an obvious negative correlation between cognition behavior control and physician-patient communication behavior. (5) A positive correlation between the intention of physician-patient communication and physician-patient communication behavior is also found. (6) There is a different outcome for different grade medical students to physician-patient communication. Suggestions: The participants were only recruited from fourth、sixth、seventh grade medical students of a public university in the south of Taiwan due to the limitation of practical situations. In the future, we recommend to include participants from private universities and lower grade medical students. If the OSCE becomes a nation examination, the research may expend to the nationwide investigation and standardization. In addition, further exploring the factors of influence medical students have on physician-patient communication ,such as sympathetic、physician-patient interaction models、personal communication characteristics 、health anxiety etc . In medical practice, we recommend further exploration in the field of communication skills、communication problems, ethics and law by clinical cases to increase the ability of communication skills and professional ethics perceived for medical students. Also, increasing subjective standards and implementing the principles of physician-patient communications through peer influence.