This study aims to interpret organizational commitment and job satisfaction among nurse anesthetists, and to explore factors and relationship between organizational commitment and job satisfaction. The study population was recruited from medical centers, regional hospitals and district hospitals, in which included Miaoli county , Taichung county, Taichung city, Nantou County, and Yunlin County. A structured questionnaire was emailed out to 430 participants and the valid questionnaires were 338. The response rate was 78.6%. Data were analyzed by SPSS v.12. t test, one-way ANOVA, Pearson’s Product-Moment the Correlation were performed for the data analysis. The results indicated that nurse anesthetists had higher affective commitment (M=20.40, SD=3.37) than continuance commitment (M=19.73, SD =3.53) and normative commitment (M=17.36, SD =3.33). Additionally, nurse anesthetists had higher intrinsic job satisfaction (M=34.67, SD=4.94) than extrinsic job satisfaction (M=31.24, SD=5.55). The organizational commitment varied according to personal characteristics, such as age, marital status, position, salary, seniority, and difference of working years at the unit (P<0.05). Furthermore, job satisfaction differed by personal characteristics, such as position, salary, and management department (P<0.05). The organizational commitment including affective commitment, continuance commitment and normative commitment were positively correlated with the intrinsic satisfaction, extrinsic satisfaction and overall job satisfaction. Based on the results, the hospital administrators, anesthetists administrators, can design a more acceptable compensation system and an education plan that will produce satisfactory and productive nurse anesthetists, and enhance the nurse anesthetists''s organizational commitment. With this improvement,the quality of nursing care then could be improved.