Pressure injury is a common problem in hospitalized patients and one of the important indicators of clinical nursing care quality. The project unit is a hematology and oncology ward. The incidence of pressure injury was 0.34% in the project unit in 2015, which was higher than the threshold set by the nursing department of that year (0.17%) in our hospital. The purpose of the project was to reduce the incidence of pressure injuries to be lower than the threshold set by the nursing department. The project team investigated the causes of pressure injury and identified three reasons: inadequate knowledge of pressure injury, a lack of continuing education for pressure injury, and a shortage of proper aiding devices. After literature review was carried out and team discussion implemented, interventions focusing on organizing continuing education, auditing the use of repositioning sheets, developing quality indicators for high-risk pressure injury patients, creating slogans to enhance patient repositioning, using appropriate dressings to prevent bruises and adding decompression equipment were all introduced. After the implementation of the above interventions, the incidence of pressure injury in the hematology and oncology ward was less than the thresholds set by the nursing department over recent years (028% in 2017, 0.08% in 2018, and 0.07% in 2019). It is hoped that this project could improve the quality of nursing care for preventing pressure injury.