This study aimed to examine the effect of telephone education programs on improving knowledge of Coronary Artery Disease (CAD) prevention, health beliefs, and preventing behaviors among CAD high-risk population. The quasi-experimental design was conducted. The education brochure was mailed to subjects in the experimental group and the telephone consultations were offered in the first, fourth and tenth week. The structural questionnaire was used to collect pre- and post- test changes between groups. A total of 43 and 41 subjects in experimental and control groups completed the study (dropout rate: 27%). The 2 group difference analysis indicated homogeneous among samples. Results of the baseline analyses revealed that subjects had medium level of knowledge (56.59±21.84), positive attitude toward health belief (2.46±0.70 in perceived susceptibility; 3.39±0.60 in seriousness; 3.31±0.57 in benefits; 1.52±0.72 in barriers) and low level of performance in prevention behaviors (2.33±0.72). After intervention, the results were as follows: 1. The experimental group had significant improvement on CAD's knowledge (t=8.91, p＜.001), perceived susceptibility (t=4.16, p＜.001), seriousness (t=4.08, p＜.001), benefits (t=4.49, p＜.001) and barriers (t=-3.51, p＜.01) in health beliefs, and preventing behaviors (t=7.27, p＜.001). 2. The experimental group’s knowledge of preventing CAD (t=5.25, p＜.001), perceived susceptibility (t=4.60, p＜.001), perceived benefits (t=2.97, p＜.01) and preventing behaviors (t=4.41, p＜.001) were better improved than that of the control group. Results of this study indicated that education brochure combined with telephone consultations were effective in improving the subjects' knowledge of CAD prevention, health beliefs, and preventing behaviors. It is suggested that this health education program should be recommended to various health institutions to detect and manage CAD high-risk population at the early stage.