Urinary catheter-associated urinary tract infection (UTI) is one of the most common nosocomial infections. The incidence of bacteriuria in patients with indwelling Urinary catheter was reported to range between 3% and 8% per day. Among patients with bacteriuria, 25% developed symptoms of UTI, whereas 1% to 4% developed bacteremia. Among patients with UTI, those with catheter-related bacteremia have a higher mortality rate than those without. Catheter-related infection has led to a substantial increase in healthcare costs. The most important risk factor for Urinary catheter-associated UTI is prolonged catheterization. Almost all patients with long-term (≥30 days) indwelling catheters developed bacteriuria. The most effective way to reduce the incidence of UTI is to restrict urinary catheterization to patients with clear indications and remove the Urinary catheter as soon as it is no longer needed. In this report, we extensively reviewed recent publications and guidelines for the diagnosis, prevention, and management of patients with urinary catheter-associated bacteriuria, both symptomatic and asymptomatic.