Reuse of space has been one of the crucial policies in Ministry of Culture, whether the reused cultural space is successful or not, management strategies play very important key roles. Hence, the purpose of this study is to explore the management strategies that activate and reuse Pu Shi Art and Culture Museum in Hualien. The research methods employed include literature analysis, direct observation and in-depth interviews to investigate the innovation of the local cultural museum, use of space; local features, creating a network platform, the value of tangible and intangible cultural creativity, and how to enhance economic activity. The management strategies based on the research will be concluded as follows (A) promote the visibility of local cultural museums (B) implement the local culture (C) stress the people's participation in community (D) train a person of culture (e) establish a sustainable management system (f) create the whole ＂cultural living area.＂ In addition, limitations and solution strategies concerning the current development of the museum are also provided.