Salmonella infection is a very important zoonosis that causes human and animal salmonellosis. Salmonella spp. are typical gastrointestinal pathogens which infect host via the oral-fecal route by contaminated food. Some asymptomatic hosts as reservoir because of Salmonella spp. could spread and then infected humans and animals. Some serotypes have host-specifity. It caused the serious gastroenteritis, enteric fever ( typhoid fever ) and septicemia in infected host. Most cases of human salmonellosis are associated with the consumption of contaminated food products such as meat, poultry, eggs, and dairy products. It’s still a big problem in public food safety, which may lead to health and economic loss. The current study was conducted to analyze the epidemiology of Salmonella spp. in pork, chicken, processing products and duck. Samples were collected on the National Animal Industry Foundation during 2009–2010, the internal transcribed spacer（ITS） region of 16S-23S rRNA as PCR primer detection target. The PCR sensitivity results revealed 100% positive. In addition, using pulsed-field gel electrophoresis ( PFGE ) to analyze Salmonella serotypes and genetic patterns, the results indicated that there are 16, mostly S. Typhimurium, S. Enteritidis and S. Schwarzengrund. The two common serovars were S. Typhimurium and S. Derby in pork. S. Enteritidis and S. Schwarzengrund were common serovars in chicken. S. Typhimurium was the most common serovars in processing products. Antimicrobial susceptibility testing showed that most of the serotypes strains were resistant to Tetracycline, Nalidxic acid and Streptomycin. The resistant drugs in the pork are Tetracycline and Streptomycin, in the chicken are Nalidxic acid, Trimethoprim-sulfamethoxazole, Tetracycline, and Amoxicillin, in the processing products are Trimethoprim -sulfamethoxazole , Tetracycline, Nalidxic acid and Streptomycin. The current data illustrated the different multidrug resistant and resistance genes by PFGE and antimicrobial susceptibility testing, suggested that inappropriate use of antibiotics might be the main cause multidrug- resistance in Salmonella spp. In conclusion, our results could be considered as the reference in Salmonella spp. prevention from the public health aspect and be eventually to reduce outbreaks and contaminations in food products due to Salmonella.