Life Cycle Assessment (LCA) is an applied method for evaluating the environmental impacts over the whole life cycle of a product, process, and activity.Therefore, LCA can be used as an assessing method in supporting systems for quantifying the environmental impacts regarding the remediation site.Life cycle assessment (LCA)methodologies are well-developed models for assessing environmental impacts including air emissions, surface water emissions, and emitting to upper soil layer. However, at the mention of emitting to groundwater and deep soil, these compartments have only gained little attention (Lemming et al. 2010).Groundwater, which is often used by people, raises the possibility of human exposure.Therefore, human health impacts may be underestimated when assessing soil and groundwater remediation alternatives. The aim of the study is to establish a method to quantify the impact of groundwater pollution by using human toxicity potential and groundwater transport model. The groundwater transport model was used to simulate the long-term emissions from pollutants, and the groundwater characterization factors were established through the multi-media transport model. By quantifying the dynamic groundwater impact, the performance of different remediation projects could be compared and supporting the availability for land reuse. The case study is a closed municipal solid waste landfill and the optional scenarios are (1) remaining the closed landfill and building a new one; (2) excavating the closed landfill and reusing; and (3) excavating the closed landfill as land reuse resource and building a new one. Among all the scenarios, scenario 1-no mining has the lowest environmental impacts. The human health impact through groundwater exposure pathway demonstrates the importance of quantifying pollution of groundwater. The III optimal remediation project could be implemented by including the dynamic groundwater impacts.