In 2016, we observed three cases of fall resulting from a lack of endurance and a neglect of nursing instructions on daily activities. These observations led to this patient care-improvement project. Cause analysis low completion rate of nursing instruction identified relevant factors including insufficient self-confidence in nursing instruction for nursing staffs and patients, resistance from patients in executing the instructions, patients' fatigue, and lack of education-assisting tools. Educational multimedia videos with QR codes, fabricated through cross-team cooperation with physical therapists and the department of education, were provided at the website of the department of nursing. Continuous education courses lectured by rehabilitation specialists were held to improve the quality and efficiency of activity instruction. Nursing instruction notes and procedures were established. Through these interventions, the completion rate of activity nursing guidance improved from 32.7% to 73.7%. Within one year after executing this project, the incidence of falls resulting from activity intolerance reduced from 0.05% to 0.02%. Monthly surveillance with patients hospitalized for 5 days or longer showed the completion rate of nursing instructions as 99.4%. The result suggests that applications of cross-team cooperation with adapting multimedia resources and developing specific sports prescriptions could efficiently improve the effectiveness of nursing instructions.