Objectives: Cancer has been the leading cause of death in Taiwan for years. In addition to curative treatments, patients with cancer can choose hospice care as a medical option. Studies indicate that hospice care could reduce medical expenditures in foreign countries, but little research has been done related to hospice care in Taiwan by using National Health Insurance Databases (NHID). Methods: Length-of-stay was compared between hospice and non-hospice cancer patients by using the NHID. After adjusting for each patient’s probability of hospice care (i.e., the propensity score, as estimated by multiple logistic regression) for randomization, average medical expenditures of two care patterns were further compared. Results: The length-of-stay of hospice and non-hospice care was 15.23 and 23.77 days, respectively. Those who underwent surgery tended to have a longer length-of-stay and those who had liver cancer tended to have a shorter length-of-stay. However, hospice patients who chose to stay in a regional hospital tended to have longer length-of-stay. The medical expenditure of hospice care was estimated to be lower, by approximately NT 40,000-220,000 dollars as compared to non-hospice care, after adjustment of propensity score methods. Conclusions: The average medical expenditure was estimated to be lower when end-of-life hospitalized cancer patients choose to have hospice as their care pattern, but home hospice and other care centers were not considered. Further research is suggested to investigate these issues and the quality and survival of hospice care in the future.