The Ministry of Education started to schedule the 12-year Education Curriculum Guide implementation in August 2019. This newly revised 12-year Education Curriculum Guide included curriculum designs for students with special needs, instead of only for regular students. This Guide promoted more cooperation opportunities between general education teachers and special education teachers; more importantly, the special education teachers' specialization in the teaching of special needs courses and the adjustment of curriculum teaching were taken into consideration. Special education teachers should have more professional skills, not only Pedagogy Knowledge and Content Knowledge but also Technology knowledge to enhance students' learning outcomes. In this article, the authors introduced Technological Pedagogical Content Knowledge (TPACK) and explored the TPACK of professional competence for special education teacher. We hope the contents can provide special educators and researchers new knowledge and enhance their existing knowledge.