There is different body composition between the spinal cord-injured person and the able-bodied which includes the muscle, fat, and bone density. Furthermore, the nerve conduction prolongs the reaction time of the gastrointestinal system. It is an important issue whether the nutritional supplements affect the performance of the athletes with spinal cord-injured or not. The purpose of this study was to investigate the effects of nutritional supplements on exercise performance in athletes with spinal cord-injured. The method of this paper was literature collection by searching Google Scholar database. Spinal cord-injured and athletes were used as the keyword when searching for literature. The scope of citation was from 1980 to 2019. We concluded that (1) Creatine supplementation is more benefit for spinal cord-injured patients than racing athletes; (2) The most acceptable concentration of carbohydrate ingestion for spinal cord-injured athletes is 7.6 ~ 11 g CHO/100 ml before 20 minutes of exercise; (3) The supplementation of caffeine and bicarbonate improve the tolerance of lactic acid and the alkalization of blood, but it does not show significant progress in exercise performance. The result of this study suggests the nutritional supplements might cause the digestive trouble during the competition therefor changed the athletes' body composition and exercise techniques could be a more important issue.