The purpose of this study was to understand the status of operating room nurses who suffer injuries from sharp instruments. The study was conducted in a 1500-bed medical center. The subjects were operating room nurses who had suffered injury from a sharp implement. The survey instrument included structured and semi-structured questionnaires, and was tested by content validity. The questionnaires were self-administrated and took 20minutes to complete. The quantitative data were analyzed by frequency, percentage, and mean, while the qualitative data were analyzed by content analysis. The results showed that 89.1% of subjects had suffered from more than two sharp injuries. More importantly, 39.1% of subjects had experienced more than five sharp injuries. Sixty-two point five percent of subjects had been injured in the year preceding the survey. Mechanisms of injuries included suture needle (31.3%) and instruments being returned by doctors (32.8%). 57.5% of subjects' fingers were injured. Most (62.0%) of subjects were in an average psychophysical state at the time of injury, and 57.5% were familiar with the surgery that was being performed. The results suggest that the standards of operating room procedures must be modified. Also, medical education is needed to stress consideration of others during surgery.