In this article, we share the experience of nursing a 28-year-old gay patient with germ cell tumor. The patient visited our hospital for neck pain and was unexpectedly diagnosed as having cancer. In addition to physical problems caused by the tumor, the patient experienced hopelessness due to pressure from his family who were unaccepting of his sexual orientation. The care period was from October 7 to October 25, 2019. Gordon's functional health assessment was performed to assess the patient's conditions, and this entailed observation, interviews, physical assessment, and medical record review. Three major health problems were identified: pain, hopelessness, and ineffective family coping. During the care period, the author based rapid adjustments to the usage of analgesics for pain alleviation on a pain management diary. Moreover, the author, along with the medical team, explained the treatment process to the patient and engaged the patient in discussion, which helped reduce his hopelessness. The author used the friendly health-care manual for lesbians, gays, bisexual and transgender individuals, and other sexual minorities to provide therapeutic support to the patient and his family, increase the family's acceptance of nonheterosexual adults, and resolve communication conflicts to ensure a positive family relationship and help the patient overcome the hardship of the treatment process. A study on lesbian, gay, and bisexual (LGB) adults reported that family acceptance among LGB individuals is the key factor for improving their self-rated physical and mental health. According to the author's clinical observation, most of LGB individuals worry that their family members will not accept their sexual orientation and experience psychological depression. Thus, early referral to an LGBTQ+ psychologist is recommended, and medical institutions should cooperate with the Taiwan Tongzhi (LGBTQ+) Hotline Association to provide multigender care services and implement LGBTQ+-friendly medical care. Our successful results encouraged us to share this nursing experience with caregivers encountering similar client situations and needs.