This study describes the ICU care experience for an 18-year-old girl with acute spondylitis complicated by lupus erythematosus, resulting in paralysis of the limbs below the belly button, as well as experience for acute plasma exchange surgery and the rehabilitation experience in the recovery period. The care period was from March 14 to March 30, 2019. Roy's adaptation model was used to perform an overall assessment, and observations, interviews, and physical assessment were used to identify the health problems and nursing problems of the patient with physical dysfunction, ineffective coping ability, and high-risk infection. A cross-disciplinary team was formed to help the patient make continual adjustments and adaptations in the physiological aspect, self-concept, role function, and mutual dependence to control the disease condition and regain normal physiological mechanisms. Art therapy, family support, and peer encouragement were used to reduce inner pressure, and somatosensory games were used to improve the activity function of the limbs, enable the patient to face significant physical changes and to positively and aggressively face the disease, improve self-confidence, accept the self, and return to campus life early. Hopefully, sharing the experience of caring for this patient may help other nursing colleagues taking care of similar patients in the future.