Journal of Occupational
Health and Epidemiology
Rafsanjan university Of medical sciences
Volume 12, Issue 2 (Spring 2023)
J Occup Health Epidemiol 2023, 12(2): 69-77 |
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Maleki H, Amin F, Parvaz N, Kahnooji M, Sayadi A, Vazirinejad R et al . ABO Blood System Associated with Susceptibility, and Rhesus (Rh) Status Associated with Disease Severity in COVID-19 Patients, (Southeast of Iran). J Occup Health Epidemiol 2023; 12 (2) :69-77
URL: http://johe.rums.ac.ir/article-1-630-en.html
URL: http://johe.rums.ac.ir/article-1-630-en.html
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Haniyeh Maleki1 
, Fatemeh Amin2 , Najmeh Parvaz1 , Mahmood Kahnooji3 , Ahmad-Reza Sayadi4 , Reza Vazirinejad * 5, Abdollah Jafarzadeh *6
, Fatemeh Amin2 , Najmeh Parvaz1 , Mahmood Kahnooji3 , Ahmad-Reza Sayadi4 , Reza Vazirinejad * 5, Abdollah Jafarzadeh *6
1- M.Sc in Clinical Biochemistry, Dept. of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Assistant Prof., Physiology‐Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.; Dept. of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Iran.
3- Assistant Prof., Dept. of Internal Medicine, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- Assistant Prof, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- Professor, Dept. of Social Medicine, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , rezavazirinejad@rums.ac.ir
6- Professor, Dept. of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Dept. of Immunology, School of Medicine, Rafsanjan, University of Medical Sciences, Rafsanjan, Iran.
2- Assistant Prof., Physiology‐Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.; Dept. of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Iran.
3- Assistant Prof., Dept. of Internal Medicine, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- Assistant Prof, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- Professor, Dept. of Social Medicine, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , rezavazirinejad@rums.ac.ir
6- Professor, Dept. of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Dept. of Immunology, School of Medicine, Rafsanjan, University of Medical Sciences, Rafsanjan, Iran.
Article history
Received: 2022/08/2
Accepted: 2023/05/20
ePublished: 2023/06/28
Accepted: 2023/05/20
ePublished: 2023/06/28
Subject:
Epidemiology
Abstract: (374 Views)
Background: The ABO/Rh blood groups were related to susceptibility to numerous infectious and non-infectious diseases. Here, the association of ABO/Rh groups with susceptibility to COVID-19 and disease severity was investigated in a population from southeast Iran.
Material and Methods: In this descriptive study, information regarding the clinical characteristics and ABO/Rh blood groups was collected from 524 patients with COVID-19 from March to October, 2020. The data of blood groups from patients were compared with those from 7365 healthy individuals during the same period. Data was analyzed using SPSS.
Results: No significant differences were found between COVID-19 patients and the healthy group regarding the proportions of A, B, and O blood groups. However, the proportion of the AB blood group was significantly higher in COVID-19 patients than that in healthy people (11.8% versus 8.2%, P <0.004). When the A group was considered as a reference, the AB blood group was associated to a greater risk of COVID-19 [OR: 1.45 (1.06-1.98), P<0.02]. No association was found between ABO blood groups and COVID-19 severity. The proportion of the Rh-positive blood group was slightly higher in COVID-19 patients than in the other group. The proportion of Rh-negative patients was greater in severe COVID-19 than in mild and moderate forms (P<0.001). In A, AB, and O blood groups, the proportions of Rh-negative patients were greater in severe COVID-19 than those with mild and moderate disease (P=0.05, P<0.05, and P<0.001, respectively).
Conclusion: The AB blood group was associated with greater susceptibility to COVID-19, while Rh-negative status was positively associated with disease severity.
Material and Methods: In this descriptive study, information regarding the clinical characteristics and ABO/Rh blood groups was collected from 524 patients with COVID-19 from March to October, 2020. The data of blood groups from patients were compared with those from 7365 healthy individuals during the same period. Data was analyzed using SPSS.
Results: No significant differences were found between COVID-19 patients and the healthy group regarding the proportions of A, B, and O blood groups. However, the proportion of the AB blood group was significantly higher in COVID-19 patients than that in healthy people (11.8% versus 8.2%, P <0.004). When the A group was considered as a reference, the AB blood group was associated to a greater risk of COVID-19 [OR: 1.45 (1.06-1.98), P<0.02]. No association was found between ABO blood groups and COVID-19 severity. The proportion of the Rh-positive blood group was slightly higher in COVID-19 patients than in the other group. The proportion of Rh-negative patients was greater in severe COVID-19 than in mild and moderate forms (P<0.001). In A, AB, and O blood groups, the proportions of Rh-negative patients were greater in severe COVID-19 than those with mild and moderate disease (P=0.05, P<0.05, and P<0.001, respectively).
Conclusion: The AB blood group was associated with greater susceptibility to COVID-19, while Rh-negative status was positively associated with disease severity.
Keywords: COVID-19 [MeSH], SARS-CoV-2 [MeSH], ABO Blood System [MeSH], Rh System [MeSH], Susceptibility [MeSH], Disease Severity [MeSH]
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