We performed a retrospective study of HCV infection in a UK teaching hospital to evaluate and compare the performance of different laboratory tests, to describe the population with active HCV infection and to determine the proportion of these individuals who access clinical review and treatment. Microbiology records for all HCV screening tests performed at Oxford University Hospitals within two defined time-intervals (Group 1 - 18 months; Jan 2013 - June 2014, Group 2 - 15 months; Jan 2015 - March 2016) were studied . For those testing positive we collected follow-up testing data. We recorded patient age, sex, and the location from which the sample was sent. We used an analytical tool to estimate ethnicity applying Onolytics software for all patients whom a full name was part of the electronic record. Ethics approval was not required, as this study was undertaken as a departmental quality improvement exercise within microbiology using anonymised patient data, and completed the audit cycle for previously approved audit projects. Data for Onolytics analysis were handled separately and were subject to a confidential disclosure agreement drawn up by University of Oxford Research Services (February 2016).
Funding
PCM received research salary from the NIHR during the course of this research and is now funded by the Wellcome Trust (grant number 110110).