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Additional file 2 of orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control

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posted on 2022-10-21, 03:24 authored by Magdalena Fernandez-Acosta, Juan I. Romero, Guillermo Bernabó, Giovanna M. Velázquez-Campos, Nerina Gonzalez, M. Lucía Mares, Santiago Werbajh, L. Amaranta Avendaño-Vázquez, Gerald N. Rechberger, Ronald P. Kühnlein, Cristina Marino-Buslje, Rafael Cantera, Carolina Rezaval, M. Fernanda Ceriani
Additional file 2 It includes all datasets and statistical analysis on which the conclusions are based. Figure 1. P[UAS] insertional mutant exhibits abnormal food-seeking behavior. Figure 2. P[UAS]100B is inserted in CG6115 and encodes a Complex I LYR domain containing protein. Figure 3. A reduction in osi levels affects viability. Figure 4. osi downregulation is associated with a smaller cell size. Figure 5. ETFRF1/LYRm5 rescues cellular and viability defects associated with osi knockdown. Figure 6. Expression of human ETFRF1/LYRm5 rescues lethality associated with osi downregulation in the fat body. Figure S7. A key role for osi in the fat body. Figure 8. osi loss of function produces a metabolic defect not rescued by antioxidants. Figure 9. Preventing excessive fat body lipid catabolism rescues the behavioral effect triggered by osi downregulation. Figure 10. osi mutants have a progressive shift in LD size. Figure 11. Reduced osi levels alters the storage lipid content and composition. Figure 12. A model for Osi function.

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Agencia I+D+i, Argentina Agencia I+D+i, Argentina Agencia I+D+i, Argentina University of Graz

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