top10-pcs_discovery_imputed-kir-hla-project.csv (1.02 MB)View fileThis item contains files with download restrictions
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imputed-hla-b-c_discovery_imputed-kir-hla-project.csv (555.62 kB)View fileThis item contains files with download restrictions
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phenotype_discovery_imputed-kir-hla-project.csv (211.12 kB)View fileThis item contains files with download restrictions
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imputed-hla-b-c_replication_imputed-kir-hla-project.csv (1.94 MB)View fileThis item contains files with download restrictions
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top10-pcs_replication_imputed-kir-hla-project.csv (5.69 MB)View fileThis item contains files with download restrictions
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imputed-kir-cn_replication_imputed-kir-hla-project.csv (9.97 MB)View fileThis item contains files with download restrictions
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phenotype_replication_imputed-kir-hla-project.csv (1.32 MB)View fileThis item contains files with download restrictions
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Datasets for "Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 with Psoriasis"
Here, we implemented KIR*IMP to impute KIR copy number and HLA*IMP to impute HLA alleles from single-nucleotide polymorphisms (SNPs) on chromosomes 6 and 19 in the discovery cohort from the PAGE consortium, University of California San Francisco, and the University of Dundee, and in a replication cohort from Kaiser Permanente Northern California. Stratified multivariate logistic regression that accounted for patient ancestry and high-risk HLA alleles revealed that KIR2DL2 copy number was significantly associated with psoriasis in the discovery cohort (p ≤ 0.05).
Funding
MHC and KIR Region Genomics in Psoriasis
National Institute of Allergy and Infectious Diseases