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High-throughput metabolomics for discovering potential biomarkers and identifying metabolic mechanisms in aging and Alzheimer’s disease

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posted on 2021-01-21, 09:42 authored by Kun XieKun Xie, Qi Qin, Zhiping LongZhiping Long, Yihui Yang, Chenghai Peng, Chunyang Xi, Liangliang Li, Zhen Wu, Volontovich Daria, Yasuang Zhao, Fan Wang, maoqing wang
To analyse the plasma metabolites related to aging, we conducted an untargeted metabolomics analysis using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry in a two-stage cross-sectional study. In total, 669 metabolites were significantly altered with aging.

Funding

Screening of biomarkers for accurate diagnosis of colorectal cancer based on methylation group and metabolome

National Natural Science Foundation of China

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Mechanism Study on the Relationship between Zinc Deficiency and Hyperglycemia Based on Multiomics Integration Analysis of Blood, Liver and Skeletal Muscle

National Natural Science Foundation of China

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Scientific Research Foundation for the Returned Overseas Scholars of Heilongjiang Province (LC2018033)

Capital Medical University (PYZ19137)

Capital’s Funds for Health Improvement and Research (CFH 2020-4-1033)

2019 Harbin Medical University Graduate Research and Practice Innovation Project (YJSKYCX2019-76HYD)

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