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Methylation and expression data for whole-genome human imprinting study

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posted on 2018-10-23, 10:08 authored by Florian ZinkFlorian Zink, Droplaug N. Magnusdottir, Olafur T. Magnusson, Nic Walker, Tiffany J.Morris, Asgeir Sigurdsson, Gisli H. Halldorsson, Sigurjon A. Gudjonsson, Pall Melsted, Helga Ingimundardottir, Snædis Kristmundsdottir, Kristjan F. Alexandersson, Anna Helgadottir, Julius Gudmundsson, Thorunn Rafnar, Ingileif Jonsdottir, Hilma Holm, Gudmundur Ingi Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Gisli Masson, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Bjarni V. Halldorsson, Simon N. Stacey, Kari Stefansson
Supplementary data for Zink et al. , "Insights into Imprinting from Parent-of-Origin Phased Methylomes and Transcriptomes", Nature Genetics (2018)

We combined whole genome oxidative bisulfite sequencing of 285 people and allele-specific RNA-seq from 11,617 blood samples with parent-of-origin (PofO) phased haplotypes, to produce a new map of imprinted methylation and gene expression patterns across the human genome.


Here we make available data files with average and PofO-specific methylation levels per CpG site, P-value for PofO-specific methylation per CpG site, and P-value for PofO-specific expression per exonic SNP, respectively


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