Title

PIMA: Protein-Protein Interactions in Macromolecular Assembly - a web server for its Analysis and Visualization

Authors

Oommen Kaleeckal Mathew^{1, 2} & Ramanathan Sowdhamini^1*

Affiliation

¹National Centre for Biological Sciences (TIFR), GKVK Campus, Bellary Road, Bangalore 560 065, India.

²SASTRA University, Tirumalaisamudram, Thanjavur 613 401, Tamil Nadu, India.

Email

mini@ncbs.res.in; *Corresponding author

Article Type

Prediction model

Date

Received December 10, 2015; Revised 28 2015; Accepted December 28, 2015; Published January 31, 2016

Protein-protein interactions are essential for the basic biological machinery of the cell. This is important for processes like protein synthesis, enzyme kinetics, molecular assembly and signal transduction. A high number of macromolecular structural complexes are known due to recent advances in structure determination techniques. Therefore, it is of interest to develop an interactive tool to objectively analyze large protein complexes. Hence, we describe the development and utility of a web enabled application named ‘Protein-Protein Interaction in Macro-molecular Assembly’ (PIMA) for the analysis of large protein assemblies. The intricate details of physical interactions amongst protein subunits in a large complex are presented as simple user preferred interactive network diagrams.

Availability

PIMA server is available for free at http://caps.ncbs.res.in/pima

Keywords

Protein-Protein interaction, macromolecule, assembly, complex, PDB, PPCheck, web server, network

Citation

Mathew & Sowdhamini, Bioinformation 12(1): 9-12 (2016)
 

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.