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2017, vol. 58, br. 1, str. 80-85
Sinteza 4,6-dimetil-3-cijano-2-piridona katalizovana aminokiselinama
Univerzitet u Beogradu, Tehnološko-metalurški fakultet, Srbija

e-adresanprlainovic@tmf.bg.ac.rs
Projekat:
Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (MPNTR - 172013)

Sažetak
U okviru rada prikazana je sinteza 4,6-dimetil-3-cijano-2-piridona katalizovana aminokiselinama. U prvom delu izvršena je optimizacija reakcije sinteze piridona varirajući početnu koncentraciju glicina, molski odnos reaktanata (acetilacetona i cijanoacetamida) i reakciono vreme. U drugom delu rada ispitan je uticaj strukture još 18 aminokiselina na prinos 4,6-dimetil-3-cijano-2-piridona. Najveći prinosi ostvareni su sa argininom (90%) i histidinom (85%) kao katalizatorima.
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O članku

jezik rada: srpski
vrsta rada: naučni članak
DOI: 10.5937/ZasMat1701080P
objavljen u SCIndeksu: 16.03.2017.
Creative Commons License 4.0

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