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2015, vol. 66, br. 2, str. 31-35
Genetic variability of the VP1 gene of BK and JC polyomaviruses in HIV-infected patients
(naslov ne postoji na srpskom)
Univerzitet u Beogradu, Medicinski fakultet, Institut za mikrobiologiju i imunologiju, Srbija

e-adresadanijela.karalic@mfub.bg.ac.rs
Ključne reči: BKV; JCV; HIV; mutacije; VP1
Sažetak
Humani poliomavirusi, BK virus (BKV) i JC virus (JCV), su široko rasp ostranj eni u humanoj populaciji. Posle primarne infekcije, BKV i JCV uspostavljaju latenciju u bubrezima i u gornjim partijama urinarnog trakta. Sporadična asimptomatska reaktivacija oba virusa se dešava kod 0.5-20% imunokompetetnih seropozitivnih osoba. S druge strane, reaktivacija kod imunosu-primiranih pacijenata, pre svega kod onih sa T ćelijskom imunodeficijencijom, može dovesti od nastanka poliomavirus-udruženih oboljenja. Neka od ovih oboljenja poput progresivne multifoklane leukoencefalopatije (PML), poliomavirus-udružene nefropatije (PVN), hemoragijskog cistitisa (HC) su životno ugrožavajuća sa visokim stepenom mortaliteta i morbiditeta. Međutim, ova oboljenja ne nastaju kod svih imunosuprimiranih osoba, ukazujući da i neki drugi faktori, poput genetičke varijabilnosti BKV i JCV mogu doprineti njihovom nastanku. Imunosupresija dovodi do povećanja nivoa virusne replikacije. Povećan nivo replikacije je povezan sa češćom pojavom mutacija u VP1 genu i ove mutacije, posebno one locirane u spoljašnjim domenima, mogu dovesi do izmene tropizma i stvaranju novih agresivnijih varijanti BKV i JCV. Akcenat u ovom revijskom radu je stavljen na klinički značaj BK i JC virusne infekcije kod imunosuprimiranih pacijenta, s posebnim osvrtom na HIV-inficirane pacijente, i na mutacije u okviru VP1 gena koje mogu doprineti evolutivnoj selekciji virulentnijih varijanti BKV i JCV.
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/medpodm1502031K
objavljen u SCIndeksu: 27.10.2016.

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