RSV infection in children aged up to 2 years

Relić, Tijana; Ilić, Nevenka; Đokić, Dragoljub; Kostić, Gordana; Veličković, Vesna; Jovanović, Dara; Tošović, Slobodan; Baskić, Dejan

doi:10.5937/medcas1103009R

Akcije

dodaj u Moj izbor [0]

kako citirati ovaj članak
prikaži na oba jezika
podeli ovaj članak

Direktan link

Metrika

citati u SCIndeksu: [2]
citati u CrossRef-u:0
citati u Google Scholaru:[]
posete u poslednjih 30 dana:6
preuzimanja u poslednjih 30 dana:4

Sadržaj

članak: 1 od 1

Medicinski časopis

2011, vol. 45, br. 3, str. 9-15

RSV infekcija kod dece uzrasta do 2 godine

Relić Tijana^a, Ilić Nevenka^b

, Đokić Dragoljub^c, Kostić Gordana^d

, Veličković Vesna^e, Jovanović Dara^a, Tošović Slobodan^a, Baskić Dejan^c

^aGradski zavod za javno zdravlje, Beograd
^bInstitut za javno zdravlje, Kragujevac
^cUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Srbija + Institut za javno zdravlje, Kragujevac
^dUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Srbija + Klinički centar Kragujevac, Klinika za pedijatriju, Srbija
^eDečiji dispanzer, Dom zdravlja, Kragujevac

e-adresa: tijana.relic@zdravlje.org.rs

Ključne reči: odojče; respiratorni tonovi; bolesti pluća; opstruktivne; respiratorni sincicijalni virusi; imunoglobulin G

Sažetak

Cilj. Respiratorni sincicijalni virus (RSV) razmatra se kao najznačajniji uzročnik akutnih respiratornih bolesti kod dece. Cilj rada je da utvrdi učestalost i karakteristike RSV infekcije kod dece sa vizingom u prve dve godine života. Metod. Ispitivanu grupu činilo je 104 deteta uzrasta do 2 godine sa vizingom. Koncentracija IgG specifičnih za RSV određivana je u uzorcima seruma ELISA metodom. Rezultati. U ispitivanoj grupi utvrđeno je 24,0% RSV IgG seropozitivne dece, pri čemu u grupi dece uzrasta do godinu dana seropozitivnost iznosi 12,9%, dok je u grupi dece u drugoj godini života 47%. Vizing, kao simptom, najčešće je bio udružen sa dijagnozom bronhitisa, u 61,5% slučajeva, dok je kod 29,8% ispitanika vizing bio udružen sa dve ili više pratećih dijagnoza. Kod dece sa postavljenom dijagnozom bronhitisa učestalost RSV IgG seropozitivnosti iznosila je 20,3%. Kod dece kod kojih je vizing bio udružen sa dve ili više pratećih dijagnoza učestalost RSV IgG seropozitivnosti bila je 32.3%, a najviši procenat RSV seropozitivnosti je zabeležen kod dece kod kojih je vizing bio udružen sa tri ili više pratećih dijagnoza (40%). U grupi dece sa jednom epizodom vizinga, bez obzira na prateću dijagnozu, učestalost RSV IgG seropozitivnosti iznosila je 19,6%, dok je u grupi dece sa recidivantnom pojavom vizinga (4 i više puta) iznosila 40,0%. Utvrđena je češća pojava RSV infekcije kod ženske dece u prvoj godini, kao i češća pojava RSV infekcije kod dece iz urbanih sredina; dojenje nije značajan faktor u prevenciji ove virusne infekcije. Zaključak. Rezultati našeg ispitivanja ukazuju na potrebu efikasnije dijagnoze respiratornih infekcija virusne etiologije i dalje proučavanje faktora rizika karakterističnih za naše podneblje kako bi se smanjio akutni morbiditet od RSV-a i hroničnih posledica ove infekcije.

Abstract

Objective. Respiratorysyncytialvirus(RSV) isconsideredto bethemost importantcause ofacuterespiratoryillnessin children. The aim of our paper was to establish the frequency and characteristics of RSV infection in infants with wheezing. Method. We examined a group of 104 infants, diagnosed with wheezing. The concentration of RSV-specific IgG was determined in the serum samples by using ELISA method. Results. We found 24.0% of RSV seropositivechildren in our studygroup, with 12.9% in the first and 47% of RSV IgGserpositive children in the second year of life. Wheezing, as a symptom, was in most cases (61.5%) associated with the diagnosis of bronchitis, whereas in 29.8% of the examined children, it was jointly manifested with two or more other diagnoses. In children diagnosed with bronchitis, the frequency of RSV IgGseropositivity was 20.3%. In those children who had wheezing jointly manifested with two or more diagnoses, the frequency of RSV IgGseropositivity was 32.3%. The greatest percentage of RSV seropositivity (i.e. 40%) was detected in those children who had wheezing and three or more jointly manifested diagnoses. In the group of children who hadhad one episode of wheezing, the frequency of RSV IgGseropositivity was 19.6%, whereas in the group of children with relapsing wheezing (i.e. 4 or more than 4) it was 40.0%. The number of RSV infections wasgreater in female infants in the first year of life and in infants coming from urban environments. Breastfeeding was not found to be a significant factor in prevention of this viral infection. Conclusion. The results of our investigations point to the need of a more effective diagnosis of respiratory infections of viral etiology and further study of local environment- specific risk factors. By knowing them better, we could be able to decrease acute RSV morbidity and chronic consequences of this infection.

	Reference
	Cane, R.S., Ranganathan, S.C., McKenzie, S.A. (2000) What do parents of wheezy children understand by 'wheeze'?. Archives of disease in childhood, 82(4): 327-32
	Carpenter, T.C., Stenmark, K.R. (2004) Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis. Pediatr Infect Dis J, 23(1 Suppl):S33-40
	Chávez-Bueno, S., Mejías, A., Welliver, R.C. (2006) Respiratory syncytial virus bronchiolitis : current and future strategies for treatment and prophylaxis. Treatments in respiratory medicine, 5(6): 483-94
	Chong, N.H.J., Rosario, N.A. (2010) Wheezing in infancy: Epidemiology, investigation, and treatment. J Pediatr, 86(3): 171-178
	de Boeck, K. (1996) Respiratory Syncytial Virus bronchiolitis: clinical aspects and epidemiology. Monaldi Arch Chest Dis, 51, str. 210-3
	Everard, M. (2009) Diagnosis, admission, discharge. Paediatr Respir Rev, 10(Suppl 1): S18-S20
	Fjaerli, H.O., Farstad, T., Bratlid, D. (2004) Hospitalisations for respiratory syncytial virus bronchiolitis in akershus, Norway, 1993-2000: a population-based retrospective study. BMC Pediatr, 4: 25
	García, C.G., Bhore, R., Soriano-Fallas, A., Trost, M., Chason, R., Ramilo, O., Mejias, A. (2010) Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis. Pediatrics, 126(6): e1453-60
	Garenne, M., Ronsmans, C., Campbell, H. (1992) The magnitude of mortality from acute respiratory infections in children under 5 years in developing countries. World health statistics quarterly. Rapport trimestriel de statistiques sanitaires mondiales, 45(2-3): 180-91
	Hajjar, S., Akhter, J., Jumaah, S., Hussain, Q.S.M. (1998) Respiratory viruses in children attending a major referral centre in Saudi Arabia. Annals of tropical paediatrics, 18(2): 87-92
	Hall, C.B., Douglas, R.G., Schnabel, K.C., Geiman, J.M. (1981) Infectivity of respiratory syncytial virus by various routes of inoculation. Infection and immunity, 33(3): 779-83
	Hall, C.B., Walsh, E.E., Schnabel, K.C., Long, C.E., McConnochie, K.M., Hildreth, S.W., Anderson, L.J. (1990) Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. Journal of infectious diseases, 162(6): 1283-90
	Hall, C.B. (1998) respiratory syncytial virus. u: Feigen RD, Cherry JD [ur.] Textbook of pediatric infectious diseases., Philadelphia: WB Saunders, 2084-111
	Handforth, J., Sharland, M., Friedland, J.S. (2004) Prevention of respiratory syncytial virus infection in infants. BMJ (Clinical research ed.), 328(7447): 1026-7
1	Holberg, C.J., Wright, A.L., Martinez, F.D., Ray, C.G., Taussig, L.M., Lebowitz, M.D. (1991) Risk factors for respiratory syncytial virus-associated lower respiratory illnesses in the first year of life. American journal of epidemiology, 133(11): 1135-51
1	Kimpen, J.L., Simoes, E.A. (2001) Respiratory syncytial virus and reactive airway disease. New developments prompt a new review. Am J Respir Crit Care Med, 163(3 Pt 2): S1
	Lanari, M., Giovannini, M., Giuffré, L., Marini, A., Rondini, G., Rossi, G.A., Merolla, R., Zuccotti, G.V., Salvioli, G.P. (2002) Prevalence of respiratory syncytial virus infection in Italian infants hospitalized for acute lower respiratory tract infections, and association between respiratory syncytial virus infection risk factors and disease severity. Pediatric pulmonology, 33(6): 458-65
1	Law, B.J., Carbonell, X., Simoes, E.A.F. (2002) An update on respiratory syncytial virus epidemiology: a developed country perspective. Respir Med, 96 Suppl B: S1-7
	Levy, M.L., Godfrey, S., Irving, C.S., Sheikh, A., Hanekom, W., Bush, A., Lachman, P. (2004) Wheeze detection: recordings vs. assessment of physician and parent. Journal of asthma, 41(8): 845-53
1	Long, C.E., McBride, J.T., Hall, C.B. (1995) Sequelae of respiratory syncytial virus infections. A role for intervention studies. American journal of respiratory and critical care medicine, 151(5): 1678-80; discussion 1680-1
	Mateos, M. (2001) Respiratory syncytial virus infection and asthma. Allergol Immunopathol, 29(3), str. 140-6
	McIntosh, K., Ellis, E.F., Hoffman, L.S., Lybass, T.G., Eller, J.J., Fulginiti, V.A. (1973) The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. Journal of pediatrics, 82(4): 578-90
	Medici, M.C., Arcangeletti, M.C., Merolla, R., Chezzi, C. (2004) Incidence of respiratory syncytial virus infection in infants and young children referred to the emergency departments for lower respiratory tract diseases in Italy. Acta bio-medica, 75(1): 26-33
1	Oddy, W.H., Holt, P.G., Sly, P.D., Read, A.W., Landau, L.I., Stanley, F.J., Kendall, G.E., Burton, P.R. (1999) Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study. BMJ (Clinical research ed.), 319(7213): 815-9
1	Ogra, P.L. (2004) Respiratory syncytial virus: The virus, the disease and the immune response. Paediatr Respir Rev, 5(Suppl A): S119-26
	Paramore, C.L., Mahadevia, P.J., Piedra, P.A. (2010) Outpatient RSV lower respiratory infections among high-risk infants and other pediatric populations. Pediatric pulmonology, 45(6): 578-84
	Resch, B., Paes, B. (2011) Are late preterm infants as susceptible to RSV infection as full term infants?. Early Hum Dev, 87(Suppl 1): S47-9
	Rusconi, F., Galassi, C., Forastiere, F., Bellasio, M., de Sario, M., Ciccone, G., Brunetti, L., Chellini, E., Corbo, G., La, G.S., Lombardi, E., Piffer, S., Talassi, F., Biggeri, A. (2007) Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children. American journal of respiratory and critical care medicine, 175(1): 16-21
1	Schauer, U., Hoffjan, S., Bittscheidt, J., Köchling, A., Hemmis, S., Bongartz, S., Stephan, V. (2002) RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life. European respiratory journal, 20(5): 1277-83
	Sefers, S.E., Li, H., Tang, Y. (2011) Simultaneous detection and differentiation of respiratory syncytial virus and other respiratory viral pathogens. Methods in molecular biology, 665: 309-23
1	Sigurs, N., Bjarnason, R., Sigurbergsson, F., Kjellman, B. (2000) Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. American journal of respiratory and critical care medicine, 161(5): 1501-7
	Tatochenko, V., Uchaikin, V., Gorelov, A., Gudkov, K., Campbell, A., Schulz, G., Prahl, R., Notario, G. (2010) Epidemiology of respiratory syncytial virus in children ≤2 years of age hospitalized with lower respiratory tract infections in the Russian Federation: a prospective, multicenter study. Clinical epidemiology, 2: 221-7
	Welliver, R.C. (1995) RSV and chronic asthma. Lancet, 346(8978): 789-90
	Wright, A.L. (2002) Epidemiology of asthma and recurrent wheeze in childhood. Clinical reviews in allergy & immunology, 22(1): 33-44
	Wright, M., Piedimonte, G. (2011) Respiratory syncytial virus prevention and therapy: Past, present, and future. Pediatric pulmonology, 46(4): 324-47
	Young, S., Sherrill, D.L., Arnott, J., Diepeveen, D., Lesouëf, P.N., Landau, L.I. (2000) Parental factors affecting respiratory function during the first year of life. Pediatric pulmonology, 29(5): 331-40

O članku

jezik rada: srpski
vrsta rada: izvorni naučni članak
DOI: 10.5937/medcas1103009R
objavljen u SCIndeksu: 20.12.2011.

Povezani članci

Nema povezanih članaka