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Medicinski časopis
2015, vol. 49, br. 1, str. 13-19
Savremeni pregled strukture vaskularnog ekstracelularnog matriksa
Tanasković Stanković Sanjaa ORCID, Sazdanović Majaa ORCID, Jovičić Nemanjaa ORCID, Milovanović Jelenaa ORCID, Lačković Milenab
aUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Srbija
bKliničko-bolnički centar Zemun, Srbija

e-adresa: sanja.tanaskovic@gmail.com
Sažetak
Vaskularni zid je sastavljen od tri osnovne strukturne komponente, endotela, glatkih mišićnih ćelija i vezivnog tkiva, koje su međusobno povezane složenim mehanizmima u jedan aktivni, visokointegrisani organ. Najveće količine vezivnog tkiva u vaskularnom zidu nalaze se u sastavu ekstracelularnog matriksa subendotela intime. Osim u subendotelu veće količine veziva smeštene su i u adventiciji. Vezivno tkivo grade ćelije i ekstracelularni matriks. U sastavu ekstracelularnog matriksa nalaze se osnovna supstanca i vezivna vlakna. Osnovna supstanca ekstracelularnog matriksa je amorfna želatinozna supstanca, sastavljena iz glikozaminoglikana, proteoglikana i strukturnih glikoproteina koji su u različitim međusobnim interakcijama, što je uslovljeno fiziološkim stanjem tkiva. Vlakna su osnovni mehaničko-potporni elementi odgovorni za čvrstinu i elastičnost vezivnog tkiva. Kolagena i retikularna vlakna sagrađena su iz proteina kolagena, dok su elastična vlakna pretežno sastavljena iz proteina elastina. Struktura i sastav komponenata ekstracelularnog matriksa, kao i njihov međusobni odnos, od suštinskog su značaja za očuvanje morfofunkcionalnih karakteristika vaskularnog zida.
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O članku

jezik rada: engleski
vrsta rada: prikaz
DOI: 10.5937/MCKG49-6844
objavljen u SCIndeksu: 02.07.2015.

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