7th Brazilian Guideline of Arterial Hypertension: Chapter 1 - Concept, Epidemiology and Primary Prevention

Concept Arterial hypertension (AH) is a multifactorial clinical condition characterized by sustained elevation of blood pressure (BP) levels ≥ 140 and/or 90 mm Hg. It is often associated with metabolic disorders, functional and/or structural changes in target organs, being worsened by the presence of other risk factors (RF), such as dyslipidemia, abdominal obesity, glucose intolerance and diabetes mellitus (DM).1,2 It is independently associated with events such as sudden death, stroke, acute myocardial infarction (AMI), heart failure (HF), peripheral arterial disease (PAD) and fatal and non-fatal chronic kidney disease (CKD).1-4

In addition, CVD account for the high frequency of hospitalizations, with high socioeconomic costs. Data from the Hospital Information System of the Brazilian Unified Public Health System point to a significant reduction in the hospitalization trend due to AH, from 98.1/100,000 inhabitants (2000) to 44.2/100,000 inhabitants (2013).
Historical hospitalization rates due to CVD by region are shown in Figure 3, with a reduction for HD and stability or reduction trend for stroke, despite the increase in hospitalizations due to IHD.

Prevalence of arterial hypertension
The prevalence of HA in Brazil varies according to the population studied and the assessment method (Table 1).
In the meta-analysis by Picon et al., the 40 cross-sectional and cohort studies included showed a reduction trend in AH prevalence in the last three decades, from 36.1% to 31.0%. 10 A study with 15,103 government employees from six Brazilian capitals has reported a 35.8% AH prevalence, with predominance of men (40.1% vs 32.2%). 11 Data from VIGITEL (2006 to 2014) indicate that the self-reported AH prevalence among individuals aged 18 years and over, living in the capitals, ranged from 23% to 25%, respectively, with no difference in the period assessed, not even regarding sex. The self-reported AH prevalence varied among adults according to age groups as follows: 18 -29 years, 2.8%; 30 -59 years, 20.6%; 60 -64   years, 44.4%; 65 -74 years, 52.7%; and ≥ 75 years, 55%. The Southeastern region showed the highest self-reported AH prevalence (23.3%), followed by the Southern (22.9%) and West-Central (21.2%) regions. The Northeastern and Northern regions had the lowest rates, 19.4% and 14.5%, respectively. 12 In 2014, the Brazilian National Health Survey (PNS) measured the BP of selected dwellers from drawn residences, using calibrated digital semi-automated devices. Three BP measurements were taken at two-minute intervals, considering the mean of the last two measurements, inserted in smartphone. The overall prevalence of BP ≥140/90 mm Hg was 22.3%, with predominance among men (25.3% vs 19.5%), ranging from 26.7% in Rio de Janeiro to 13.2% in Amazonas, with predominance in the urban area as compared to the rural one (21.7% vs 19.8%).

Knowledge, treatment and control
A review 7 has shown a wide variation of BP knowledge (22% to 77%), treatment (11.4% to 77.5%) and control (10.1% to 35.5%) rates, depending on the population studied (Table 2).

Prehypertension
Prehypertension (PH) is characterized by systolic BP (SBP) between 121 and 139 and/or diastolic BP (DBP) between 81 and 89 mm Hg. 13 The world prevalence of PH has ranged from 21% to 37,7% in population-based studies, except for Iran (52.1%) (Figure 4). 14 Prehypertension associates with a higher risk of developing AH 15,16 and cardiac abnormalities. 17 Approximately one third of the cardiovascular (CV) events attributed to BP elevation occur in individuals with PH. 18 Meta-analyses of the incidence of CVD, IHD and stroke in prehypertensive individuals have shown a higher risk among those with BP levels between 130 and 139 or 85 and 89 mm Hg than among those with BP levels between 120 and 129 or 80 and 84 mm Hg ( Figure 5). 14 The clinical implication of that epidemiological evidence is that the BP of prehypertensive individuals should be monitored closely, because a significant proportion of them will develop AH and its complications. 2

Age
There is a direct and linear association between aging and AH prevalence related to the increase: i) in life expectancy of the Brazilian population, currently 74.9 years; ii) in the elderly population ≥ 60 years in the past decade (2000 to 2010), from 6.7% to 10.8%. 19 A meta-analysis of studies performed in Brazil including 13,978 elderly has shown a 68% AH prevalence. 20

Sex and ethnicity
The 2013 Brazilian National Health Survey (PNS) showed a self-reported AH prevalence statistically different between sexes, being higher among women (24.2%) and black

Salt intake
The excessive consumption of sodium, one of the major RF for AH, associates with CV and renal events. 22,23 In Brazil, data of the Survey on Family Income (POF), collect from 55,970 dwellings, have shown home availability of 4.7g of sodium/person/day (adjusted for the consumption of 2,000 kcal), exceeding more than twice the maximum recommended consumption (2 g/day), lower in the urban area of the Southeastern region, and higher in the rural area of the Northern region. 24 The impact of the sodium-rich diet estimated in the 2014 VIGITEL data showed that only 15.5% of the individuals interviewed acknowledged high or extremely high salt content in their meals. 12

Alcohol intake
A chronic and high consumption of alcoholic beverages increases BP consistently. A meta-analysis of 2012, including 16 studies with 33,904 men and 19,372 women compared the consumption intensity between non-drinkers and drinkers. 25 For women, there was a protective effect with doses lower than 10g of alcohol/day, and risk for AH with a consumption of 30-40g of alcohol/day. For men, the increased risk for AH became consistent from 31g of alcohol/day onwards.
The 2006-2013 VIGITEL data showed that abusive alcohol consumption -at least four doses for women, or at least five doses for men, of alcoholic beverages on the same occasion, within the past 30 days -is stable in the adult population, around 16.4% (24.2% for men and 9.7% for women). For both sexes, abusive alcohol consumption was more often among youngsters, and increased with schooling. 25

Sedentary lifestyle
A population-based study in the city of Cuiabá, Mato Grosso State, (n = 1,298 adults ≥ 18 years) has revealed a 75.8% overall prevalence of sedentary lifestyle (33.6% during leisure time; 19.9% at work; 22.3% during both). A significant association of AH was observed with age, male sex, overweight, central adiposity, sedentary lifestyle during leisure time and work, less than 8 years of schooling, per capita income < 3 minimum wages. 26 Brazilian National Health Survey (PNS) data indicate that insufficiently active individuals (adults not practicing at least 150 minutes per week of physical activity including leisure, work and displacement time) represent 46.0% of the adults, the percentage being significantly higher among women (51.5%). The frequencies of insufficiently active individuals differed between age groups, mainly among the elderly (62.7%) and the adults with no formal education and those with incomplete elementary education (50.6%). 27

Socioeconomic factors
Adults with lower schooling (no formal education or incomplete elementary education) have a higher prevalence of self-reported AH (31.1%). The proportion decreases among those with complete elementary education (16.7%), being 18.2% among those with complete higher education. 26 However, the ELSA Brazil Study, performed with employees of six Brazilian universities and university-affiliated hospitals with higher schooling, has shown a 35.8% AH prevalence, higher among men. 11

Genetics
Brazilian studies assessing the impact of genetic polymorphisms in the quilombola population could not identify a more prevalent pattern, showing the strong impact of miscegenation, and hindering the identification of a genetic pattern for the elevation of BP levels. 28,29 Strategies for the implementation of preventive measures The strategies for preventing the development of AH comprise public policies for health in combination with action from the medical societies and communication media. They should be aimed at stimulating early diagnosis, continuous treatment, control of BP and associated RF, by use of lifestyle changes and/or regular use of medications.