Spontaneous Dissection Of Left Anterior Descending Coronary Artery: Case Report

Mailing Address: Cybelle Nunes Leão Hospital Santa Isabel Rua Frei Cornélio, 200. Postal Code: 36500-000, Laurindo de Castro, Ubá, Minas Gerais Brazil. E-mail: cynunesleao@gmail.com Spontaneous Dissection Of Left Anterior Descending Coronary Artery: Case Report Cybelle Nunes Leão,1 Marilia Medeiros Vitório Machareth,1 Pedro Henrique D'avila Costa Ribeiro,2 Bruno dos Santos Farnetano,1 Isaac Nilton Fernandes Oliveira,1 Rafael Américo Damaceno1 Hospital Santa Isabel,1 Ubá, MG Brazil Faculdade Governador Ozanam Coelho,2 Ubá, MG Brazil


Introduction
4][5][6] However, as has been observed in more recent studies, the prevalence of SCAD has increased due to the growth in the use of coronary angiography (from 0.2% to 4%). 5 Because it is a poorly studied disease, its etiology remains little known and, therefore, the prognosis and therapeutic approach are still uncertain. 1,6,7he percutaneous coronary intervention, surgical myocardial revascularization and clinical treatment are therapeutic options. 3,5,8

Case Report
A 26-year-old female, with no cardiovascular risk factors (arterial hypertension, diabetes mellitus, dyslipidemia, smoking and alcoholism) or other relevant pathological antecedents, under use of oral contraceptives only, woke up due to oppressive precordial pain associated with diaphoresis and dyspnea.
After seeking medical attention, she was admitted to an emergency care unit in her hometown 18 hours after the beginning of the clinical picture.The electrocardiogram showed ST elevation in leads V1 and V2 and ST-segment depression in leads DII, DIII and aVF.
After administration of acetylsalicylic acid (ASA) 200 mg, she was referred to a referral hospital.Afterwards, the patient was hemodynamically stable, with sinus cardiac rhythm, eupneic, normotensive and with decreased pain.A coronary angiography was carried out 24 hours after the beginning of the symptoms and revealed dissection from the ostium to the proximal third of the ADA, with 90% obstruction and intramural thrombus (Figure 1), in addition to left ventricular anteroapical akinesia.The other coronary arteries showed no obstructive lesions.
Because the patient was hemodynamically stable and had no precordial pain, a non-interventionist strategy was chosen through clinical treatment of SCAD.A double antiplatelet therapy was started, with clopidogrel (loading dose of 300 mg followed by 75 mg/day maintenance dose) and ASA (loading dose of 200 mg and 100 mg/ day maintenance dose), in adittion to full anticoagulation with enoxaparin (2mg/kg/day divided into 2 doses per day).After 8 days of treatment, an intravascular ultrasonography (IVUS) and a new coronary angiography were performed, confirming the finding of anterior descending CAD and significantly improved artery stenosis with 50% blockage in the proximal part.The exams did not evidentiate aortic arch disease.
The IVUS confirmed the finding of anterior descending coronary artery dissection and showed the presence of intramural hematoma with a thrombosed false lumen (Figure 2).Minimum lumen area of 5.5mm².
The patient was discharged after 12 days from the beginning of the symptoms.She was asymptomatic and the markers of myocardial necrosis were normal.She was instructed to maintain the use of ASA and clopidogrel and scheduled a new imaging examination (coronary angiography or coronary angiotomography) for six months after the acute event.

Discussion
6][7] In patients with SCAD, in addition to the symptoms of ACS, in up to 50% of cases, the ECG shows ST elevation and significantly elevated troponin. 2owever, due to the rarity of this disease, it is usually forgotten as a differential diagnosis in ACS and, in most cases (70%), the diagnosis is made by necropsy, in such a way that its real incidence is underestimated. 1,3,4,9ere is a marked predominance in women, with a proportion of 3 to 1 compared to men.About one-third of cases occur during pregnancy or in the puerperal period. 7However, Yip and Saw1 suggest, in their study, these data might have been biased in older studies, since they present selective case reports of high morbidity and mortality.
In women, dissections usually occur when they are young, with a mean age of 40 years, with no risk factors for ACS, and mostly affect the left coronary artery. 3,5,7,9n men, the impairment occurs at a higher age range, sometimes associated with the presence of risk factors for coronary artery disease, with a predominant involvement of the right coronary artery. 7In general, the anterior descending artery is affected in up to 75% of cases. 3,5,7,97][8] Intracoronary imaging techniques, such as the IVUS and optical coherence tomography, are crucial to establish the diagnosis, therapeutic decisions and prognosis. 3,5,9hrough retrospective studies, it is possible to observe that adequate treatment varies depending on the clinical severity of the disease, considering the persistence or the relief of the symptoms of ischemia, the patient's hemodynamic condition, the myocardium area at risk, the extension of the dissection, the number of arteries involved and the distal coronary flow. 4,7,9w et al., 3 in a revision study, designed an algorithm for the management of patients with SCAD, presenting the following basic concepts: 1) The conservative therapy is performed in stable patients, who are monitored in hospital from 3 to 5 days; 2) The revascularization, including coronary percutaneous intervention, if possible, should be considered for those with high-risk characteristics; 3) The use of intra-aortic balloon, oxygenation by extracorporeal membrane, left ventricular assist device or implantable cardioverter defibrillators should be considered in hemodynamically unstable patients.
In spite of its rarity, SCAD is an important cause of ACS and should always be considered in the differential diagnosis, particularly when it occurs in young healthy women.Intracoronary imaging can be used both to confirm the diagnosis and to guide the treatment decisions and, in combination with data provided by previous studies, help to define a more adequate therapeutic strategy, according to each type of disease presentation.

Figure 1 -
Figure 1 -Left coronary angiography in the right anterior oblique projection with caudal angulation demonstrates a 90% stenosis of the ostium and a negative image suggestive of a thrombus in the proximal third of the artery.

Figure 2 -
Figure 2 -Intravascular ultrasonography of the proximal third of the anterior descending artery, performed 8 days after the first coronary angiography, showing intramural hematoma with thrombi at 4-11h.