African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2280

Full Length Research Paper

Evaluation of the modulatory and antibacterial activity of the ethanolic extract and fractions of Duguetia furfuracea A. St.-Hil.

Cicera Norma Fernandes
  • Cicera Norma Fernandes
  • Laboratory of Molecular Pharmacology and Chemistry, Regional University of Cariri, Crato (CE), Brazil.
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Heloisa Helena Ferreira Sousa
  • Heloisa Helena Ferreira Sousa
  • Laboratory of Molecular Pharmacology and Chemistry, Regional University of Cariri, Crato (CE), Brazil.
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Maria Cristina Melo Borges
  • Maria Cristina Melo Borges
  • Laboratory of Molecular Pharmacology and Chemistry, Regional University of Cariri, Crato (CE), Brazil.
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Celestina Elba Sobral Souza
  • Celestina Elba Sobral Souza
  • Laboratory of Molecular Biology and Microbiology, Regional University of Cariri, Crato (CE), Brazil.
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Glaucia Morgana Melo Guedes
  • Glaucia Morgana Melo Guedes
  • Laboratory of Molecular Biology and Microbiology, Regional University of Cariri, Crato (CE), Brazil.
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Fernando Gomes Figueredo
  • Fernando Gomes Figueredo
  • Laboratory of Molecular Biology and Microbiology, Regional University of Cariri, Crato (CE), Brazil.
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Saulo Relison Tintino
  • Saulo Relison Tintino
  • Laboratory of Molecular Biology and Microbiology, Regional University of Cariri, Crato (CE), Brazil.
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José Galberto Martins Costa
  • José Galberto Martins Costa
  • Research Laboratory of Natural Products, Regional University of Cariri, Crato (CE), Brazil.
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Henrique Douglas Melo Coutinho
  • Henrique Douglas Melo Coutinho
  • Laboratory of Molecular Biology and Microbiology, Regional University of Cariri, Crato (CE), Brazil.
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Irwin Rose Alencar Menezes
  • Irwin Rose Alencar Menezes
  • Laboratory of Molecular Pharmacology and Chemistry, Regional University of Cariri, Crato (CE), Brazil.
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Cícero Francisco Bezerra Felipe
  • Cícero Francisco Bezerra Felipe
  • Laboratory of Molecular Pharmacology and Chemistry, Regional University of Cariri, Crato (CE), Brazil.
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Marta Regina Kerntopf
  • Marta Regina Kerntopf
  • Laboratory of Molecular Pharmacology and Chemistry, Regional University of Cariri, Crato (CE), Brazil.
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  •  Accepted: 30 December 2013
  •  Published: 08 January 2014

Abstract

Medicinal plants have been the subject of research in several countries such as Brazil. The Duguetia furfuracea A. St.-Hil., popularly known as araticum-bravo, ata-brava and ata de lobo, has been used in folk medicine as anti-rheumatic drugs, for the treatment of renal dysfunction, spinal pain and stomach, and against pediculosis. This work aimed to analyze the antibacterial effect of the crude extract and fractions obtained from the leaves of D. furfuracea. The characterization of secondary metabolites was carried out through phytochemical prospection, being checked for the presence of tannins, flavonoids and alkaloids. The minimum inhibitory concentration (MIC) was determined by using broth microdilution method and its modulating activity of antibiotic activity in sub-inhibitory (MIC/8) concentration. When standard bacterial strain is used for the MIC and multidrug-resistant strains of modulation, all samples had a MIC ≥ 1024 µg/ml. The samples when combined with aminoglycosides demonstrated synergistic activity against the Escherichia coli 27 and Staphylococcus aureus 358. The results of this study indicate the species D. furfuracea as a promising source in combating bacterial multidrug resistance, increasing the potential of antibiotics.

Key words: Duguetia furfuracea A. St.-Hil., modulation, antibacterial activity, aminoglycosides.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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