Abstract

This study was designed to investigate the effect of hydroxy safflower yellow A (HSYA) on inflammatory reaction in ratmyocardium after acute myocardial infarction (AMI). 138 male Wistar rats were randomly divided into six groups: normal group, sham group, control group, injecting SY positive control group (SY group, 90 mg/kg), HSYA high-dose group (HSYA-H group, 40 mg/kg), and HSYA low-dose group (HSYA-L group, 20 mg/kg), n = 23. The AMI injury of rats was induced by ligating the anterior descending coronary artery. After the treatment of drugs, the concentrations of IL-1β and IL-6 in serum of the rats on HSYA-H, HSYA-L and SY groups significantly decreased when compared with those of the rats in the control group (P<0.05). The percentage of cells with the positive expressions of NF-κB and CRP in the drug treatment groups significantly decreased when compared with those of cells in the control group (P<0.05). Moreover, when compared with those of NF-κB in the control group, mRNA and protein expressions of NF-κB in myocardium in SY, HSY-L and HSY-H groups significantly decreased (P<0.05). In addition, the mRNA and protein expressions of NF-κB in myocardium in HSY-H group significantly decreased (P<0.05).HSY-A and SY can reduce the levels of hs-CRP, IL-1β and IL-6 in serum of the AMI rats. The inhibitory effect of HSY-A on inflammation is the main mechanism to improve AMI rats.

Key words: hydroxy safflower yellow A; acute myocardial infarction; inflammation