Integral Treatment of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown etiology. The prevalence of SLE is worldwide from 4 to 250 per 100,000. Statistics demonstrate that lupus is somewhat more frequent in Africans, Americans and people of Chinese and Japanese descent. It is a disease with predominance of the female sex, the ratio among SLE sufferers is about 9:1. It is often discovered in their childbearing years. It affects heterogeneity multiple organs of the body and presents aberrant immunological findings and especially the presence of antinuclear antibodies. The clinical course and prognosis is unpredictable and may be characterized by periods of remissions and chronic or acute relapses. The mortality rate among patients with SLE is at least three times that of the general population. (Aberer, 2010; Ng & Chan, 2007; Ramirez, 2007)


Introduction
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown etiology. The prevalence of SLE is worldwide from 4 to 250 per 100,000. Statistics demonstrate that lupus is somewhat more frequent in Africans, Americans and people of Chinese and Japanese descent. It is a disease with predominance of the female sex, the ratio among SLE sufferers is about 9:1. It is often discovered in their childbearing years. It affects heterogeneity multiple organs of the body and presents aberrant immunological findings and especially the presence of antinuclear antibodies. The clinical course and prognosis is unpredictable and may be characterized by periods of remissions and chronic or acute relapses. The mortality rate among patients with SLE is at least three times that of the general population. (Aberer, 2010;Ng & Chan, 2007;Ramírez, 2007)

Etiopathogenesis
The etiopathogenesis that causes lupus is not known. Interactions between susceptibility genes and environmental factors result in abnormal immune responses. The antigens, autoantibodies, and immune complexes persist for prolonged periods of time, allowing inflammation and contribute to irreversible tissue damage developing the disease. The SLE is a multigenic disease. In most genetically susceptible individuals, if enough variations accumulate multiple genes they contribute to abnormal immune responses and disease results. Some genes influence clinical manifestations of disease in various ethnic groups. (Javierre & Richardson, 2011;Koike, 2011) The SLE is more frequent in female sex. The females make higher antibody responses than the males. The estrogens favour a prolonged immune response increasing the risk of developing SLE. Several environmental stimuli may influence in the development of the SLE. Exposure to ultraviolet light causes skin injures in approximately 70% of SLE patients. Some infections, for example Epstein-Barr virus (EBV), induce abnormal immune response. Occasionally, some drugs stimulate the immune system and can induce SLE. The extreme stress may trigger the illness. (Ng & Chan, 2007;Niller et al,2011;Nowicka-Sauer, 2007;Ramírez, 2007) values (C3 and C4), IFN-inducible genes, soluble IL-2, and urinary adiponectin or monocyte chemotactic protein 1. In the diagnosis of SLE there is no single symptom or finding that is sufficient in itself, it is based on the clinical and the laboratory and on the American Rheumatism Association (ARA) classification criteria. Any combination of 4 of 11 criteria makes it likely that the patient has SLE. See TABLE 1. Antinuclear antibodies (ANA) are positive in more 98% of patients during the course of disease; repeated negative tests suggest that the diagnosis is not SLE. The antibodies to double-stranded DNA and antibodies to the Sm antigen, specific for SLE, with compatible clinical favor the diagnosis. The presence in an individual of multiple autoantibodies without clinical symptoms should not be considered diagnostic for SLE, although such persons are at increased risk since clinical SLE begins in most patients years after autoantibodies appear. (Nakashima et al, 2011)

Disease activity
The disease activity indices have been created at standardizing the SLE activity assessment. Some of such indices are: European Consensus Lupus Activity Measurement (ECLAM), Lupus Activity Index (LAI), British Isles Lupus Assessment Group (BILAG), Lupus symptom inventory (LSI) and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The ECLAM assesses disease activity over the last month, and comprises 15 clinical and laboratory parameters. Its scores ranges are from 0 to 10. (Griffiths et al, 2005) The LAI comprises four scores to assess clinical activity: physician's global evaluation, opinion of the doctor about disease severity, laboratory findings and immunosuppressive treatment. Its scores ranges are from 0 to 3. (Griffiths et al, 2005) The BILAG index measures SLE disease activity. It is composed of eight organ-based systems: general symptoms, mucocutaneous, respiratory, cardiovascular, neurological, musculoskeletal, renal and hematological. It is represented with alphabetical letters depending of the clinical characteristics present and their behavior during one month. BILAG "A" represents the presence of one or more severe SLE characteristics. BILAG "B" indicates more moderate characteristics of the disease. BILAG "C" includes mild symptomatic characteristics. BILAG "D" represents the previous activity. BILAG "E" indicates that a system has never been involved. (Isenberg et al, 2005) The LSI measures clinical activity in the last month. It includes five main symptoms: flares, headaches, joint inflammation, muscles and weakness. Its score ranges are from 1 to 5. The higher score is the symptoms with more severity (Duvdevany et al, 2011) The SLEDAI assesses disease activity in the previous ten days. It evaluates the organ affected, clinical and laboratory parameters. The scores greater than 8 indicates active disease. A three-point variation between medical visits indicates disease activation, and variations greater than or equal to 12 points mean severe activity. It was reviewed in the year 2000, originating SLEDAI-2K. The modifications included the persistence of rash, mucosal ulcers, alopecia, and proteinuria greater than 0.5 in 24h and had ability to differentiate clearly active patients from inactive ones or those with minimum activity. (Freire al, 2011)

Damage caused by SLE
The damage indices in organ-based systems can be used as a health measure in patients with chronic diseases. The damage caused by SLE has reference a symptom present at least six months that develops in tissue damage which produces irreversible organ damage. It detects damages in patients which can have resulted from disease activity or treatment or comorbidities. The ACR published the Systemic Lupus International Collaborating Clinics/American College of Rheumatology -Damage Index (SLICC/ACR-DI), in 1996. This instrument approaches 12 organ-based systems. The damages caused by SLE affect to patients who result in physical or/and mental disabilities, worsening the patient's quality of life, which is an important indicator of the health status of patients with chronic diseases. (Freire al, 2011)

Psychological and social diagnosis
The committee on Outcome Measures in Rheumatology Clinical Trials (OMERACT) of the ACR has recognized the importance of measure function and wellbeing from the patient's view as a criterion to determine clinical improvement. The psychological and social diagnosis can be obtain through data collection via a semistructured interview performed by the same physician and measured about the illness perception of the own patient, experienced thought and behavior by chronic illness, the role of personality and coping with stressful life situations and social relationships. (Freire et al, 2011;Ramírez, 2007)

Illness perception
The model proposes by Leventhal support that self-regulatory patients are active problemsolvers who seek to make sense of illness and form illness perceptions that influence coping strategies. These representations of illness are composed of cognitions about the name of the illness and its associated symptoms, timeline, causes, personal control and understanding, effectiveness of its treatment. These disease perceptions determine how individuals respond to illness in their emotions, behavior, health care, expectations, attitude to the illness, coping, functioning and cooperation with health professionals. (Kaptein & Broadbent, 2007;Nowicka-Sauer, 2007) The methods used to assess illness perception are verbal and nonverbal tools. Among nonverbal are: Pictorial Representation of Illness and Self-Measure (PRISM) and drawing. Among verbal are the Brief-Illness Perception Questionnaire (B-IPQ). (Broadbent et al, 2006;Nowicka-Sauer, 2007).

Pictorial representation of illness and self-measure
Büchi et al have developed the Pictorial Representation of Illness and Self-Measure (PRISM). It is a measure of the "burden of suffering" due to illness from the patient's perspective that includes factors directly related to the disease, disease-related intrusion in relevant aspects of life, like family, work or friendship. The burden of suffering is a subjective experience arising out of or identified by means of one´s awareness of his own states or processes, even clinician with great experience derived from direct observation (facial expression, body posture, signs of sorrow, etc) are unable to detect the inner feelings of their patient. PRISM is a measure, by simplicity of use, that is easily understood by patients and widely accepted by them.
A red disk , 5cm in diameter with magnet on the underside were given to the patient , this disk represents his/her illness and the patient is also presented with a metal board which has a fixed yellow disk 7cm in diameter at the bottom right hand corner, this yellow disk represents the patient "self". The patient is then asked "where in your life (board) would you put the (illness) disk at the moment?" The distance between the two disks, representing Illness and Self respectively, is inversely related to the burden of the illness. This distance, measured is called the Self-Illness Separation (SIS). The possible range of SIS is 0±27 cm. PRISM can be used in people with SLE in everyday clinical practice as a quantitative assessment instrument of patient-focussed health. (Buchi et al, 1998;Buchi et al, 2000) Drawing The drawings allow to assess patients views on how are the heterogeneity of clinical presentations, variety of illness perception, understanding and experiences of the SLE patients. This method help to talk, it makes the patients open up to their emotions, views, and experiences. It improves understanding of these patients in a short amount of time. Together with questionnaire assessment, the drawings can be an important source of information on how the illness can be experienced and felt and how it influences patients emotions and behaviors. (Daleboudt et al, 2011;Nowicka-Sauer, 2007)

Brief-Illness Perception Questionnaire (B-IPQ)
The B-IPQ contains eight items to score on a scale from 0 to 10 and one open-ended question where the participants have to state the three most important causes for their disease. A mean score is calculated for every scale and the reported causes can be grouped into categories on the basis of common themes. The B-IPQ has been shown to be a valid and reliable measure to assess illness perceptions in ill populations, but no validation for patients with SLE has been done. (Broadbent et al, 2006).

Cognitive-behavioral analysis
The experience of chronic illness, one like SLE, could become for the patient the focus of all its daily attention, decreasing the time devoted to family, friends, work, or developing as a person. The ill could focus his time on trying to control or avoid his disease with its emotions, sensations, memories, or thoughts producing human suffering that restrict healthy behavior. There are measures widely used for clinical outcomes, that assess human sufferers produced by chronic illness. These are: Beck Depression Inventory (BDI), Pain Anxiety Symptoms Scale (PASS), Sickness Impact Profile (SIP), Chronic Pain Acceptance Questionnaire (CPAQ), Mindful Attention Awareness Scale (MAAS), Chronic Pain Values Inventory (CPVI).

Beck Depression Inventory
The Beck Depression Inventory (BDI) is a measure of depression and general emotional distress. It has 21 items. Each scored goes from zero (neutral) to three (maximum severity). The BDI range is from zero to sixty three. The twenty is a cutoff for clinically significant symptoms. (Beck et al, 1988;

Pain Anxiety Symptoms Scale
The Pain Anxiety Symptoms Scale (PASS) is a measure of anxiety responses and avoidance related to chronic pain. The original version is a 40-item measure. Patients indicate the frequency of anxiety from zero (never) to five (always). The total score ranges from zero to two hundred. The PASS includes subscales: cognitive anxiety symptoms, escape and avoidance, fearful thinking and physiological anxiety responses. The PASS-20 is a new version of PASS-40. It is a 20-item measure. It assesses of fear, avoidance, cognitive, and anxiety responses related to chronic pain. The rate each item goes from zero (never) to five (always) indicating how the patients do or experience each of the actions or thoughts described. McCracken & Yang, 2006;Roelofs et al, 2004) Sickness Impact Profile The Sickness Impact Profile (SIP) is used to assess physical and psychosocial disability on daily functioning. It is a 136-item measure. It has three domains (physical, psychosocial and other aspects of disability) and twelve categories of daily functioning. The categories can be scored separately or combined with domains. The categories in the physical domain are ambulation, mobility, body care and movement. The categories in the psychosocial domain include social interaction, alertness behavior and emotional behavior. The categories in the other domain are sleep and rest, eating, home management, recreation and pastimes, work and communication. The patients, when answering the SIP, endorse statements that describe problems in relation to their health. All scores range from 0 to 1. Higher scores indicate greater disability. (McCracken & Yang, 2006; Chronic Pain Acceptance Questionnaire The Chronic Pain Acceptance Questionnaire (CPAQ) is a measure of acceptance of chronic pain. It is a 20-item inventory. Each item has a scale of zero (never true) to six (always true). The total score ranges from zero to one hundred and twenty. It has two subscales: activity engagement (eleven items) and pain willingness (nine items). The activity engagement measures tendency to perform usual daily activities regardless of pain present. The pain willingness measures the relative absence of attempts to control or avoid pain present.

Mindful Attention Awareness Scale
The Mindful Attention Awareness Scale (MAAS) is a measure of mindfulness. It is a 15-item inventory. Each item is rated on a scale from one (almost always) to six (almost never). The items content reflects the opposite of mindfulness or mindlessness. The items of the lower frequency are taken to represent a higher level of mindfulness. The items greater than eighty correlate with measures of emotional distress and physical symptoms. (Brown and Ryan, 2003;

Chronic Pain Values Inventory
The Chronic Pain Values Inventory (CPVI) is based on the acceptance and commitment therapy. It assesses two scores: success and the discrepancy between importance and success in six domains of patient values. The first set considers the values and rates the importance of these patients in each domain. The second set rates how these persons have lived according to their values in each domain. The values domains are: family, intimate relations, friends, work, health, and growth or learning. The rates of each item go from zero (not at all important/successful) to five (extremely important/successful). Low success in living in accord with an unimportant value produces less suffering than low success living in accord with important value. (McCracken & Yang, 2006)

Personality and coping variables
The capacities of patient to cope with stress to go off defence mechanisms that result in the psychological response to determine as these persons are living with the SLE. (Eriksson & Lindstrom, 2005)

Defence mechanisms
The defence mechanisms are defined by American Psychiatric Association as "automatic psychological processes that protect the individual against anxiety and from the awareness of internal or external dangers and stressors, mediating the individual's reactions to emotional conflicts and to internal or external stressors". (American Psychiatric Association.

Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR, 1994)
The Defence Style Questionnaire (DSQ-88) estimate behaviour indicating four defence styles: namely maladaptive action, image-distorting, self-sacrificing and adaptive styles. The Hostility and Direction of Hostility Questionnaire (HDHQ) provides a measure of hostility that reflects an attitudinal personality trait and shows the participant's reaction to frustrating occurrences. These questionnaires have been used with rheumatic patients. (Bai et al, 2009;Hyphantis et al,2006;Hyphantis, 2010)

Sense of coherence
The sense of coherence (SOC) introduced by Antonovsky, is defined as "a global life orientation that expresses the extent to which one has a pervasive, enduring though dynamic sense of confidence that the stimuli deriving from one's internal and external environments in the course of living are structural, predictable, and explicable; the resources are available to one to meet the demands posed by the stimuli; and these demands are worthy of investment and engagement". The SOC scale assesses the three dimensions: comprehensibility, manageability, and meaningfulness. It is an instrument measuring of global orientation how people manage stressful situations, not to measure each of the three core components separately. In patients with SLE, have been found correlations between SOC scores and physical and psychological quality of life components. The use of SOC scale detect those patients who are coping poorly with the illness because they have poor psychological resources, in order to promote psychotherapeutic interventions that improve patients' QOL. (Abu-Shakra et al, 2006;Hyphantis et al, 2011)

Quality of life
The quality of life (QOL) has been defined by WHO as "individuals perceptions of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns". (WHOQOL Group, 1995) As health-related QOL scales are measures centered on the patient's opinion. It assessments the patient's health status throughout the disease and their satisfaction with treatment. These instruments are very used because these persons are the most interested in their own outcome. (Freire et al, 2011) The instruments for QOL assessment can be self-administered or interview-administered. It can be generic or specific for a certain disease. Some generic instruments are the WHOQOL and Short Form 36-item Health Survey Questionnaire (SF-36

WHOQOL
The World Health Organization (WHO) has developed an international quality of life assessment. This measure shows physical, psychological and social well-being of patients connecting with the WHO's definition of quality of life. In clinical practice, the WHOQOL assessments help clinicians to discover the areas in which a patient is most affected by disease, and to decide about treatment. The WHOQOL exists in twenty nine languages, contain hundred questions group by domains and sub-domains of quality of life. These are: I Physical Capacity (1 Pain and discomfort, 2 Energy and fatigue, 3 Sleep and rest), II Psychological (4 Positive feelings, 5 Thinking, learning, memory and concentration, 6 Self-esteem, 7 Bodily image and appearance, 8 Negative feelings), III Level of Independence (9 Mobility, 10 Activities of daily living, 11 Dependence on medication or treatments, 12 Work capacity), IV Social Relationships (13 Personal relationships, 14 Social support, 15 Sexual activity), V Environment (16 Physical safety and security, 17 Home environment, 18 Financial resources, 19 Health and social care: accessibility and quality, 20 Opportunities for acquiring new information and skills, 21 Participation in and opportunities for recreation/ leisure activities, 22 Physical environment (pollution/noise/traffic/climate), 23 Transport), VI Spirituality/Religion/ Personal Beliefs. (WHOQOL Group, 1995).

Short Form 36-item Health Survey Questionnaire
The Short Form 36-item Health Survey Questionnaire (SF-36) is a generic instrument for QOL assessment. It is a questionnaire with thirty-six items, grouped into the eight domains, which are: physical function, role limitations due to physical health, pain, general health perception, vitality, social function, role limitations due to emotional problems, and mental health. It summarize the results in two areas: physical and psychological. The score ranges are from zero to hundred and are directly proportional to the state of health.. There are validation studies in SLE patients, in a variety of socio-cultural contexts using many languages SF-36 versions. The SF-36 was recommended as the instrument of choice for measuring HRQOL in SLE. (Freire el al, 2011;Thumboo & Strand, 2007)

Systemic Lupus Erythematosus Symptom Checklist
The Systemic Lupus Erythematosus Symptom Checklist (SSC) measure the impact of the disease and its treatment on the individual. This questionnaire study 38 symptoms in a fourpoint scale, where zero is the best health status and four, the worst. (Freire et el, 2011;Sanchez et al, 2009;Thumboo & Strand, 2007)

Systemic Lupus Erythematosus Quality of Life Questionnaire
The Systemic Lupus Erythematosus Quality of Life Questionnaire (SLEQOL) has 40 items into the six domains: physical function, occupational activity, symptoms, treatment, mood and self-image. The scores vary from one to seven, and the lower (fourty) the score is the best the QOL and the higher (two hundred and eighty) the score is the worse QOL. This questionnaire showed to have more sensitivity to changes over time than SF-36. (Freire et el, 2011;Sanchez et al, 2009;Thumboo & Strand, 2007)

Systemic Lupus Erythematosus Needs Questionnaire
The Systemic Lupus Erythematosus Needs Questionnaire (SLENQ) has seven domains: that assess the following needs: psychological-spiritual-existential, health services, health information, physical, social support, daily living, and employment. This questionnaire showed moderate correlations with SF-36. (Moses et al, 2007;Freire et el, 2011).

Lupus Quality of Life
The Lupus Quality of Life (LupusQOL) contains thirty four items in eight domains: physical health, emotional health, body image, pain, planning, fatigue, intimate relationships and burden to others. (Freire et el, 2011;McElhone et al, 2007;Sanchez et al, 2009;Thumboo & Strand, 2007) Cross-sectional studies and prospective studies have identified the age, the duration, the activity and damage disease, some specific manifestations of SLE as fatigue, pain or endstage renal failure, the corticosteroids or cytotoxic, the knowledge of lupus, the illness related behaviours, the educational status, the self-efficacy, the learned helplessness, the ability to work, the home environment and the social support as factors associated may influence health-related quality of life (HRQOL) in SLE patients. (McElhone K et al, 2006;Navarrete-Navarrete et al, 2010;Thumboo & Strand, 2007)

Treatment
The SLE is no curable and complete remissions are rare, sometimes is cyclical and sometimes is progressive, is heterogeneous in manifestations and has significant mortality risk. It is a disease that requires lifelong treatment. SLE may have a higher impact on patients' life than other chronic illnesses, and the level of impact may be influenced by type of treatment. SLE is a disease that can significantly impact physiological, psychological and social functioning, influencing in health-related quality of life of the patients. The pharmacologic and non-pharmacologic therapies may have an additive or synergistic effect on improving on these patients HRQOL (Daleboudt et al, 2011;Thumboo & Strand, 2007).

Patient-centred care
The treatment of SLE's people should be patient-centred ensuring that the patients are treated with dignity and respect. Good communication between doctors and patients is essential. These ills and their families and carers need a high-quality communication, supported by evidence-based information that provides treatment and care based on best practice. Patients should have the opportunity to be involved in the decisions about their treatment and care. The physician should take into account needs and preferences of the patients. Families and carers should have the information and support they need. Information, treatment and care should be given at patients, families and carers by culturally appropriate written information tailored to their needs. (Michalski & Kodner , 2010;van der Giesen et al, 2007;Villanueva, 2009)

Multidisciplinary treatment
SLE is a complex disease. Healthcare professionals of these patients must pay careful attention to all items of illness (physical, psychological, family and social) in multidisciplinary cooperation. It is the most frequent that patient comes at primary care physicians. The American College of Rheumatology Ad Hoc Committee on SLE guidelines recommends that primary care physicians should refer SLE patients to rheumatologists to establish SLE definitive diagnosis, activity and severity disease and treatment of general disease and some medication side effects. Rheumatologists should work with a multidisciplinary team allowing coordinated care of patient. This includes family physicians, other specialist physicians, psychotherapies, rehabilitations, nurses and social workers. Family Medicine is a specialty focused person-centred care. Competent and polyvalent family physicians may be allowed to attend the patient in his/her whole life. From primary care should monitored ill a long time and treated when presents other pathologies or some medication side effects (infection, cardiovascular disease, osteoporosis,) or mild symptom SLE. From other specialist physicians should treat damaged major organ. From psychotherapy should teach coping strategies to favor psychosocial adjustment. (Aberer, 2010;Beckerman et al, 2011;Michalski & Kodner , 2010;Ramírez, 2007;Taylor & McMurray, 2011;van der Giesen et al, 2007;Villanueva, 2009)

Physical treatment
Medical treatment and a recommended lifestyle are necessary for optimal functioning in life SLE patients. The pharmacological treatment is always individual. It depends if it is to control acute, severe flares or to develop maintenance strategies that suppress symptoms and prevent organ damage. This therapy also depends on adverse effects of medications, whether disease manifestations are life-threatening or to cause organ damage, whether manifestations are potentially reversible and the best approaches to preventing complications of disease. (Michalski & Kodner , 2010;Taylor & McMurray, 2011;Yildirim-Torner C & Diamond B, 2011.) The most important drugs are: nonsteroidal anti-inflammatory drugs, hydroxychloroquine corticosteroids, immunosuppressive drugs (azathioprine, cyclophosphamide, methotrexate, mycophenolate). Almost all patients should take hydroxychloroquine and most corticosteroids with immunosuppressive drugs. With better management, patients with lupus live longer but are at increased risk of disease and treatment-related complications, including infection, cardiovascular disease, and osteoporosis. (Michalski & Kodner , 2010;Taylor & McMurray, 2011;Yildiri-Toruner C & Diamond B, 2011.) Pharmacologic and biologic therapies reducing disease activity and/or levels of anti-dsDNA antibodies improving HRQOL for SLE patients. (Thumboo & Strand, 2007;Dall'era & Chakravarty, 2011) The damages disease in skin or alopecia can be improved with treatment of these lesions and/or use of cosmetics to camouflage these lesions. The use of a highly protective broad-spectrum (UVB and UVA) sunscreen can effectively prevent skin photosensitive lesions in patients's SLE. (Kuhn et al, 2011;Obermoser & Zelger B, 2008 ;Thumboo & Strand, 2007)

Psychological and social treatment
The psychotherapy programs should help to equip the SLE's patients with knowledge and skills of coping for managing the illness and to build up familiar and social support. The patients with rheumatic illness experience significant restrictions into their daily life. There are researches that prove that the cognitive behavioral therapy (coping methods and contextual methods) improves on these persons their experience of physical symptom (pain, fatigue), daily activity, psychology and social functioning.
Although there are few researches on SLE's patients, the cognitive behavioral therapy (CBT) (coping methods and contextual methods) reaches above average levels in physical functioning, psychic functioning and social functioning obtaining a significant improvement in the HRQOL, independent of the activity level of the disease. (McCracken & Vowles, 2008;Navarrete-Navarrete et al, 2010;Ramírez, 2007)

Psychotherapy methods
The behavioral therapy is in a state of development. Actually, there are three generations. They are based on chosen strategies the two firsts direct change, coping methods, and the third indirect change, contextual methods. The coping methods are focused on control or change in the content of psychological experiences and the contextual methods include acceptance, mindfulness and values. These therapies are characterized: the first by behavioral change, the second by cognitive models and the third by processes of acceptance and values-based action. They are integrative and not exclusive, they encompass each other. In these therapies the problems are rationalized and contextualized and the sensations produced by them can improve experience and acceptance. The psychotherapy that use coping methods includes: understanding SLE providing information, understanding one's rights as a patient, controlling pain and fatigue oneself, teaching stress management through concept of stress and relaxation techniques (diaphragm breathing and deep muscle relaxation), alternative thought control strategies that help to manage frustration and emotion (self-instructional training and thought stopping), humour and optimism as coping strategies, cognitive restructuring (identifying and discussing the consequences of main errors in thinking, main core beliefs, challenging thoughts), demonstrating problem-solving skills, developing personal strengths, training in social skills (assertiveness techniques, how to say no without feeling bad, asking another person to change their behavior) locating community resources for rehabilitation. (Navarrete-Navarrete et al, 2010;Ng P & Chan, 2007;Ramírez, 2007;Robles-Ortega & Peralta-Ramírez, 2006;Sheldon,1995) The psychotherapy that includes contextual methods is acceptance and commitment therapy (ACT) and mindfulness. The ACT centers on building positive and flexible behavior patterns rather than removing symptoms carrying up processes of acceptance, contact with the present moment and values-based action. This model includes: acceptance, cognitive defusion, contact with the present moment, self-as-context, values and committed action (Hayes et al, 2006). The studies with this treatment on patient's rheumatic illness are very up to date. (McCracken & Vowles, 2008) Mindfulness is a technique and a component of the acceptance and commitment therapy. It can be understood as attention, awareness and reflection of present moment nonjudgmental. This model include: nonconceptual, focused on the present, non-judgmental, intentional, participatory observation, emotional, exploratory and liberating. The researches with this technique on patient's rheumatic are also very up to date. (Germer et al, 2005)

Psychotherapy in SLE
The patients with SLE live with fears about the illness because they have nothing or little knowledge about the clinic, treatment and prognosis of the illness. The researches have shown that to improve the understanding of these persons with accurate information of the mechanisms of SLE contribute to a better adjustment to live with their illness because their negative beliefs about it are reduced influencing on their self-esteem. (Ng P & Chan, 2007)

Chronic pain
The chronic pain is a great suffering for SLE's patient. The medical and surgical treatments may produce variable results and adverse events and iatrogenic complications on any patient with chronic pain. The use of other means for pain reduction, as the programs of physical activity may reduce pain improving HRQOL in these ills. The subjective nature of pain makes complicated this problem. The pain is a response to nociception on the patient influenced by genetic, personal history, physiologic state and psychological and social context. And the pain influences on physical, psychological and social functioning. The patients with chronic pain may be influenced by distressing thoughts and emotions and ineffective behaviors focusing on their pain. The increasing attempts to control pain may be associated with increasing the limits of their functioning interfering with healthy living. An alternative approach, are personal's choice of adaptive responses adjusted to chronic pain. The research has shown the utility of ACT. The experienced pain, with control, allows more healthy activities. The acceptance-oriented responses to chronic pain may improve physical (disability), psychological (suffering) and social (working) functioning over time. The positive purposes of families and friends, with more patient attitude about behavior pattern, may make easier the processes of acceptance. The mindfulness-based treatment methods are addressed to these patients suffering chronic pain. The mindfulness is based: present-focused, realistic contact with pain, neutral awareness of pain, change experience pain and effective behavioral. Mindfulness is observation and commitment. The researches show mindfulness may get better well-being of patients with chronic pain. It gives them more realistic experiences and more effective flexible behavioral. Thumboo & Strand, 2007)

Fatigue
Fatigue is lack of energy, physical and mental tiredness. On SLE's patients, it compromises quality of life, reducing psychological well-being, because these difficulties on daily activities affect personal and social life. Fatigue is present on many chronic ills, for example: multiple sclerosis, cancer, chronic fatigue syndrome, rheumatoid arthritis, SLE. The physiopathology of fatigue in SLE have been difficult to identify but likely to be multifactorial. Fatigue may be associated with SLE disease process and with pain, lack of physical exertion, sleep disturbance, depression, anxiety, stressful life events, infection, medication side effects and characteristics of the local environment (lighting and temperature). (Bakshi 2003;Dittner et al, 2004 ;Godaert et al, 2002 ;Neill, 2005 ;Zifko, 2004). Researches for reducing fatigue in people with SLE are few and show strategies not completely effective in the long-term. The treatment of chronic illnesses fatigue usually combines pharmacological and nonpharmacological therapy. Pharmacological therapy efficacy is questioned in fatigue of SLE's patients and nonpharmacological therapy is essential for her management. This therapy include exercise, rehabilitation programmes and cognitive behavioral therapy. (Godaert et al, 2002) Studies suggest aerobic exercise is effective for reducing fatigue in some people with SLE. This exercise includes low-impact aerobics, walking, cycling, and jogging. It should be appropriate for each ill and take into account individual fluctuations in fatigue intensity, if feasible, it might be executed home-based or in supervised classes. This exercise should begin early in the disease course or following the disease, start with low intensity activities and avoid provoking symptoms, gradually increasing in intensity, duration and frequency, combine aerobic and resistance training where possible. It is recommended to carry out between fifteen and thirty minutes at least three times weekly if it is tolerated. This exercise type appears to be effective in reducing fatigue in patient with cancer and chronic fatigue syndrome. (Mancuso et al, 2010;Stricker et al. 2004 ;Watson & Mock, 2004). Fatigue is a variable and subjective experience that may decline inactive life-style disproportionally affecting physical activity, psychological and societal participation. In this case, it might be required to promote interventions of self-management of fatigue and better illness cognitions and coping styles by means of CBT. Cognitive behavioural therapy helps to identify and to challenge perpetuating factors. These are: insufficient coping with the disease and dysfunctional cognitions about fatigue such as lack of control and catastrophizing (negative thoughts are put into reality perspective), deregulation of sleep (to adhere biologic rhythm and to fixed bedtimes and wake-up times during the day), deregulation of activity (a base level activity and alternating rest and activity should be established), low social interactions (to favor realistic expectations toward the participation in social relations). Studies show that cognitive behavioural therapy with/without exercise is effective in reducing fatigue in chronic fatigue syndrome, multiple sclerosis, cancer-related fatigue and SLE because it improves self-efficacy, increasing their quality of life. (Edmonds et al, 2004;Navarrete-Navarrete et al, 2010;Neill et al, 2006;Wagner & Cella, 2004)

Neuropsychiatric manifestations
Cognitive dysfunction, anxiety and depression are frequent in patient's SLE. The consequences of SLE living may impact personal life, including interpersonal relationships and professional rol. The majority of SLE patients present depression and emotional distress. These affective disturbances are very rarely attributed to disease activity alone, and may influence psychosocial factors. Cognitive dysfunction may coexists with psychiatric disorders. Their association in SLE is not clear. Some study shows the psychological state of the ill may influence self-reporting of cognitive problems (Farrin et al, 2003;Kozora et al, 2006;Kozora et al, 2007;Nowicka-Sauer et al, 2011;Panopalis et al, 2007;Vogel et al, 2011;Zakeri et al, 2011.) Neuropsychiatric manifestations should be diagnosed and treated in these patients first as if they had not SLE, and secondarily as if they had it.  Clinical guideline about care of patients with depression and a chronic physical health problem recommend physical activity programme and cognitive behavioural therapy. (NICE, 2009) Cognitive behavioural therapy sets up role cognitive representations or perceptions and emotional responses of patient's SLE that can influence individual's ability to manage his illness by selecting coping strategies. The ill may organize an individual's response around five cognitives. These include: representation of their illness, perceived duration, unpredictability, control, perceived of severity and cause. There are researches that show better depressive symptoms and cognitive dysfunction in patient SLE following cognitive behavioural therapy. Greco et al, 2004;Philip et al, 2009) www.intechopen.com Challenges in Rheumatology 184

Conclusion
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown etiology, with predominance of the female sex in their childbearing years. SLE affects heterogeneity multiple organs of the body and presents aberrant immunological findings. The clinical course and prognosis is unpredictable. It can affect sociopsychologically to patients experiencing high levels of emotional distress by affecting physical, pharmacology treatment, their own worries about illness, abnormal illness-related behaviours and affecting social life. The integral diagnosis in the patients with SLE include the aspects: physical, psychological and social. The physical diagnosis of SLE is based on the clinical and the laboratory and on the American Rheumatism Association (ARA) classification criteria. The psychological and social diagnosis can be obtain through data collection via a semi-structured interview performed by the same physician and measure about the illness perception of the own patient, experienced thought and behavior by chronic illness, the role of personality and coping with stressful life situations and social relationships. The integral treatment of patient's SLE include pharmacological and non-pharmacological therapies that may have an additive or synergistic effect on these patients. These treatment should be patient-centred favouring high-quality communication between doctors and patients with their families and carers supported by evidence-based information that provides treatment and care based on best practice. These patients should be treatment by multidisciplinary team that include family physicians, rheumatologists, other specialist physicians, psychotherapies, rehabilitations, nurses and social workers. Pharmacological treatment and recommended lifestyle are always individual and necessary for optimal functioning in life SLE patients. The psychotherapy should help to equip the SLE's patients, that experience significant restrictions into their daily life, with knowledge and skills of coping for managing the illness and to build up familiar and social support. The cognitive behavioural therapy (coping methods: behavioural change and cognitive models, and contextual methods: acceptance and commitment therapy and mindfulness) improves on these persons their experience of physical symptom (pain, fatigue,…), daily activity, psychology and social functioning.

Key points
1. The SLE is a chronic inflammatory autoimmune disease of unknown etiology with predominance on the female sex in their childbearing years. 2. The SLE affects heterogeneity multiple organs of the body and presents aberrant immunological findings. 3. The clinical course and prognosis of SLE is unpredictable, it is a disease no cure. 4. The SLE affect patient's bio-psycho-social unit. 5. The integral diagnosis in patients with SLE includes : physical, psychological and social aspects. 6. The treatment of SLE patients should be physical, psychological and social. 7. The treatment of SLE's people should be patient-centred. 8. Healthcare to SLE patients should be multidisciplinary including rheumatologists, family physicians, other specialist physicians, psychotherapies, rehabilitations, nurses and social workers.
9. Medical treatment and a recommended lifestyle are necessary for optimal functioning in the life of SLE patients. 10. The psychotherapy programs should help to equip the SLE's patients with knowledge and skills of coping for managing the illness and to build up familiar and social support. 11. The cognitive behavioural therapy (coping methods and contextual methods) improves on the persons' SLE their experience of physical symptom (pain, fatigue, neuropsychiatric manifestations), daily activity, psychology and social functioning.