Exosomes: Mechanisms of Uptake

Authors

  • Kelly J. McKelvey Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia
  • Katie L. Powell Pathology North, NSW Health Pathology at Royal North Shore Hospital, St Leonards, NSW, Australia
  • Anthony W. Ashton Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia
  • Jonathan M. Morris Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, NSW, Australia
  • Sharon A. McCracken Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia

DOI:

https://doi.org/10.33393/jcb.2015.2057

Keywords:

Exosome, immunology, endocytosis

Abstract

Exosomes are 30–100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

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Published

2015-07-17

How to Cite

McKelvey, K. J., Powell, K. L., Ashton, A. W., Morris, J. M., & McCracken, S. A. (2015). Exosomes: Mechanisms of Uptake. Journal of Circulating Biomarkers, 4(1). https://doi.org/10.33393/jcb.2015.2057

Issue

Vol. 4 No. 1 (2015): January-December 2015

Section

Review

License

Authors contributing to Journal of Circulating Biomarkers agree to publish their articles under the Creative Common Attribution Non Commercial 4.0 (CC-BY-NC 4.0) license, which allows third parties to re-use the work without permission as long as the work is properly referenced and the use is non-commercial.

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