Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy

Akira Suzuki; Satoshi Yamaguchi; Ming Li; Yasuhiro Hara; Hideyuki Miyauchi; Yoshihiko Ikeda; Bo Zhang; Masahiro Higashi; Yasuyuki Ikeda; Atsuko Takagi; Hironori Nagasaka; Kunihisa Kobayashi; Yasuhiro Magata; Toshiaki Aoyama; Ken-ichi Hirano

doi:10.5650/jos.ess18037

Nutrition and Health Function

Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy

Akira Suzuki, Satoshi Yamaguchi, Ming Li, Yasuhiro Hara, Hideyuki Miyauchi, Yoshihiko Ikeda, Bo Zhang, Masahiro Higashi, Yasuyuki Ikeda, Atsuko Takagi, Hironori Nagasaka, Kunihisa Kobayashi, Yasuhiro Magata, Toshiaki Aoyama, Ken-ichi Hirano

Author information

Akira Suzuki
Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University
Satoshi Yamaguchi
Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University
Ming Li
Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University
Yasuhiro Hara
Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University
Hideyuki Miyauchi
Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine
Yoshihiko Ikeda
Department of Pathology, National Cerebral and Cardiovascular Center
Bo Zhang
Department of Biochemistry, Fukuoka University Medical School
Masahiro Higashi
Department of Radiology, Osaka National Hospital
Yasuyuki Ikeda
Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University
Atsuko Takagi
Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University
Hironori Nagasaka
Department of Pediatrics, Takarazuka City Hospital
Kunihisa Kobayashi
Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital
Yasuhiro Magata
Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine
Toshiaki Aoyama
Daitocacao Co.,LTD.
Ken-ichi Hirano
Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University

Keywords: adipose triglyceride lipase, capric acid, iodine-123-β-methyl iodophenyl-pentadecanoic acid, medium-chain triglyceride, tricaprin, triglyceride deposit cardiomyovasculopathy

JOURNAL FREE ACCESS

2018 Volume 67 Issue 8 Pages 983-989

DOI https://doi.org/10.5650/jos.ess18037

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Abstract

Triglyceride deposit cardiomyovasculopathy (TGCV) is an intractable cardiovascular disease for which a specific treatment is urgently required. In TGCV, adipose triglyceride lipase (ATGL) deficiency results in the abnormal intracellular metabolism of long-chain fatty acid (LCFA) which leads to TG deposition. Medium-chain triglycerides have been used as an important functional food for various human diseases. To address the potential activities of tricaprin, a medium-chain triglyceride, on cardiac dysfunctions of TGCV, we examined the effects of tricaprin diet on Atgl knock out (KO) mice, an animal model for TGCV. Cardiac imaging tests showed that the tricaprin diet reduced TG accumulation, resulting from improvement of LCFA metabolism, and improved left ventricular function in Atgl KO mice compared to that in mice fed the control diet. In conclusion, tricaprin improved myocardial abnormality in the TGCV model, thus, it may be useful for the treatment of patients with TGCV.

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