医療薬学
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
点眼剤の使用性に関する検討 (第1報)
点眼容器の押し出し力 (スクイズ力) と点眼液滴下量の変動
倉本 美佳樋上 智子高橋 佳子檜垣 文子山下 典子合田 昌子足立 亜紀子室 親明橋本 肇濱口 常男門林 宗男
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2004 年 30 巻 1 号 p. 13-19

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We examined the usability of eleven brands of ophthalmic solution available on the market. This involved measuring the squeezing force on ophthalmic solution containers and drop volume using a force gauge. We also examined the usability of the ophthalmic solution containers for our subjects with regard to the ease of squeezing out the contents. The squeezing force on containers differed among products, ranging from 0.7 kg (Tobramycin) to 2.9 kg (Levocabastine hydrochloride). For five products, there was a large change in the squeezing force on the container between the beginning and the end of the usage period, the coefficients of variation of which ranged from 6.9 % to 16%. The drop volume differed among products ranging from 34 mg (Ibudilast, Tropicamide) to 49 mg (Levofloxacin). There were three products with a large change in the drop volume during the usage period, the coefficients of variation of which ranged from 12.2% to 22.2%. Ibudilast had a particularly large change in drop volume during the usage period. The usability test with our subjects showed that usability decreased when the squeezing force for a container was 1.5 kg or more. Our findings showed that it would be effective to use the variation in the squeezing force and drop volume during the usage period as an index when evaluating the usability of ophthalmic solutions.

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