Mechanism of Action of Many Drugs Depend on Enzyme Inhibition

Authors

  • Rezk R. Ayyad Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, ALAZHAR University, Cairo, Egypt
  • Ahmed M. Nejm Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, ALAZHAR University, Cairo, Egypt
  • Yasser Abdel Allem Hassan Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Addaqahlya, Egypt
  • Ahmed R. Ayyad Faculty of Medicine, Asfendiyarov Kazakh National Medical University (KazNMU)

Keywords:

enzyme inhibition, beta-lactamase inhibitors, gyrase enzyme inhibitors, pteridine synthetase inhibitors, dihydrofolate inhibitors, angiotensin-converting enzyme inhibitors, HMG-CoA reductase inhibitors, phosphodiesterase inhibitors, cholinesterase inhibitors, carbonic anhydrase inhibitors, bacteriostatic, bactericidall, antibiotic, anti-hypertensive

Abstract

Enzyme inhibition is an important process in the mode of action of many drugs used in the treatment of various diseases. Antibiotics, anti-hypertensive agents, anti-hyperlipidaemic, anti-glaucoma, and anti-malarial drugs act on specific enzymes, leading to bacteriostatic or bactericidal effects, lower blood pressure, reduce cholesterol levels, and cause smooth muscle relaxation of blood vessels. Understanding the mode of action of these drugs and how they affect enzymes is crucial for the development of new drugs and the optimization of existing therapies. This article highlights some various drugs that act through enzyme inhibition and their mechanisms of action.

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Published

2023-10-10

Issue

Vol. 2 No. 4 (2023): December

Section

Articles