CLOREXIDINA E PREVENÇÃO DE PNEUMONIA ASSOCIADA À VENTILAÇÃO MECÂNICA: REVISÃO INTEGRATIVA SOBRE INCIDÊNCIA DE PAV E MORTALIDADE

Authors

  • Gabriela da Costa Gomes
  • Stefany Paes Landim Mendes
  • Marcos Barbosa Pains

DOI:

https://doi.org/10.56083/RCV4N1-240

Keywords:

Clorexidina, Pneumonia Associada à Ventilação Mecânica, Higiene Bucal

Abstract

A Pneumonia Associada à Ventilação Mecânica (PAV) é uma infecção frequente em Unidades de Terapia Intensiva (UTIs), apresentando elevadas taxas de mortalidade. A manutenção de uma higiene bucal adequada desempenha papel crucial na prevenção sendo a clorexidina a principal substância empregada para esse fim. No entanto, persistem incertezas em relação ao uso indiscriminado dessa substância. Objetivos: Este estudo visa avaliar a eficácia comparativa da clorexidina e substâncias inertes na prevenção da PAV e mortalidade em pacientes sob ventilação mecânica. Metodologia: A pesquisa no Pubmed, de 2013 a 2023, resultou em 194 artigos, e a manual 182, com 12 artigos selecionados para inclusão na revisão integrativa. O Grupo Teste (clorexidina) teve 779 pacientes, o Grupo Controle (substâncias inertes) envolveu 302 pacientes. A análise comparativa focou na incidência de PAV e taxa de mortalidade. Resultados: No Grupo Teste, 19.78% desenvolveram PAV, com taxa de mortalidade de 8,22%. No Grupo Controle, a incidência de PAV foi 18.54%, com taxa de mortalidade de 8.61%. Conclusão: Apesar de este estudo não ser conclusivo, a utilização generalizada da clorexidina em todos os pacientes não parece ser justificada, já que não apresentou melhorias na incidência de PAV, embora também não tenha acarretado aumento na taxa de mortalidade.

References

BELLISSIMO-RODRIGUES, W. T. et al. “Oral mucositis as a pathway for fatal outcome among critically ill patients exposed to chlorhexidine: post hoc analysis of a randomized clinical trial.” Critical care (London, England) vol. 23,1 382. 27 Nov. 2019, doi:10.1186/s13054-019-2664-6. DOI: https://doi.org/10.1186/s13054-019-2664-6

BERRY, A. M. A comparison of Listerine® and sodium bicarbonate oral cleansing solutions on dental plaque colonisation and incidence of ventilator associated pneumonia in mechanically ventilated patients: A randomised control trial. Intensive and Critical Care Nursing, Edinburgh, v. 29, n. 5, p. 275 - 281. Oct. 2013. DOI: https://doi.org/10.1016/j.iccn.2013.01.002

BOOKER, S. et. al. Mouth care to reduceventilator-associated pneumonia.Am J Nurs, 2013 Oct;113 (10): 24-30; quiz 31. Doi: 10.1097/01.NAJ.0000435343.38287.3a. DOI: https://doi.org/10.1097/01.NAJ.0000435343.38287.3a

BOUADMA, L; KLOMPAS, M. Oral care with chlorhexidine: beware!. 2018. Intensive Care Med, 2018 Jul; 44 (7): 1153-1155. Doi: 10.1007/s00134-018-5221-x. DOI: https://doi.org/10.1007/s00134-018-5221-x

CHACKO, R. et. al. Oral decontamination techniques and ventilator-associated pneumonia. British Journal of Nursing. v. 26, n. 11, p. 594 - 599. 2017. Doi. 10.12968/bjon.2017.26.11.594 DOI: https://doi.org/10.12968/bjon.2017.26.11.594

COLLARD, HR; SANJAY, S; MATTHAY, MA. Prevention of ventilator-associated pneumonia: an evidence- based systemic review. Ann Intern Med. 2003; 138: 494-501. DOI: https://doi.org/10.7326/0003-4819-138-6-200303180-00015

CAMARGO, L; SILVANA, S; CHAMBRONE, L. Efficacy of toothbrushing procedures performed in intensive care units in reducing the risk of ventilator‐associated pneumonia: A systematic review.J Periodont Res. 2019; 00:1–11. DOI: 10.1111/jre.12668. DOI: https://doi.org/10.1111/jre.12668

DESCHEPPER, M. et. al. Effects of chlorhexidinegluconate oral care on hospital mortality: a hospital-wide, observational cohort study. Intensive Care Med. 2018;44:1017–1026. DOI: https://doi.org/10.1007/s00134-018-5171-3

DeRISO, et al. “Chlorhexidine gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery.” Chest vol. 109,6 (1996): 1556-61. doi:10.1378/chest.109.6.1556 DOI: https://doi.org/10.1378/chest.109.6.1556

FEIDER, LL; MITCHELL, P; BRIDGES, E. Oral care practices for orally intubated critically ill adults.Am J CritCare. 2010; 19 (2): 175-83. Disponível em: http://doi.org/10.4037/ajcc2010816. DOI: https://doi.org/10.4037/ajcc2010816

HUA, F. et. al. Oral care with chlorhexidine seems effective for reducing the incidence of ventilator-associated pneumonia. Cochrane Database Syst Rev 2016; 10: Art. No: CD008367.DOI:10.1002/14651858.CD008367.pub3. DOI: https://doi.org/10.1002/14651858.CD008367.pub3

IZADI, M, et al. Reduce the risk of ventilator-associated pneumonia in ICU patients by Ozonated water mouthwash: A double-blind randomized clinical trial. American JournalofInfectionControl. v.51, n. 7, p. 779 - 785. 2023 doi:10.1016/j.ajic.2022.10.015 DOI: https://doi.org/10.1016/j.ajic.2022.10.015

JAHANSHIR, M. et al. Effect of clove mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: a comparative randomized triple-blind clinical trial. Clinical oral investigations. v. 27, n. 7, p. 3589 - 3600. 2023. doi:10.1007/s00784-023-04972-w DOI: https://doi.org/10.1007/s00784-023-04972-w

JORDAN, A. et. al. Factors influencing intensive care nurses’ knowledge and attitudes regarding ventilator-associated pneumonia and oral care practice in intubated patients in Croatia. Am J Infect Control [Internet]. 2014; 42 (10): 1115-7. Disponível em: http://doi.org/10.1016/j.ajic.2014.07.008. DOI: https://doi.org/10.1016/j.ajic.2014.07.008

KES, D. et al. Effectof 0.12% Chlorhexidine Use for Oral CareonVentilator-Associated RespiratoryInfections: A RandomizedControlledTrial. Journalof trauma nursing : theofficialjournaloftheSocietyof Trauma Nurses v. 28,4. July/Aug. 2021: 228-234. Doi:10.1097/JTN.0000000000000590 DOI: https://doi.org/10.1097/JTN.0000000000000590

KLOMPAS, M. et. al. Reappraisal of Routine Oral Care With ChlorhexidineGluconate for Patients Receiving Mechanical Ventilation: Systematic Review and MetaAnalysis. JAMA InternMed. 2014; 174 (5): 751-761. Doi:10.1001/jamainternmed. 2014.359.

KLOMPAS, M. Associations Between Ventilator Bundle Components and Outcomes. JAMA Intern Med. Doi:10.1001/jamainternmed. 2016. 2427. DOI: https://doi.org/10.1001/jamainternmed.2016.2427

KLOMPAS, M. et. al. Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals. 2022 Update. Infection Control & Hospital Epidemiology (2022), 1–27. DOI: https://doi.org/10.1017/ice.2022.88

KUSAHARA, D; PETERLINI, M; PEDREIRA, M. Oral care with 0.12% chlorhexidine for the prevention of ventilator-associated pneumonia in critically ill children: randomised, controlled and double blind trial. Randomized Controlled Trial.Int J Nurs Stud. 2012 Nov; 49 (11): 1354-63. Doi: 10.1016/j.ijnurstu.2012.06.005. Epub 2012 Jul 7. DOI: https://doi.org/10.1016/j.ijnurstu.2012.06.005

LEE. S et al. Chlorhexidine-RelatedMortality Rate in CriticallyIllSubjects in IntensiveCareUnits: A SystematicReviewand Meta-Analysis. Respiratorycare vol. 64,3. 2019: 337-349. doi:10.4187/respcare.06434 DOI: https://doi.org/10.4187/respcare.06434

MEIDANI, M. et al. Oropharyngeal Irrigation to Prevent Ventilator-Associated-Pneumonia: Comparing Potassium Permangenate with Chlorhexidine. International journal of preventive medicine. v. 9, p, 93. 2018, doi:10.4103/ijpvm.IJPVM_370_17 DOI: https://doi.org/10.4103/ijpvm.IJPVM_370_17

MEINBERG, MC. et. al. The use of 2% chlorhexidine gel and toothbrushing for oral hygiene of patients receiving mechanical ventilation: effects on ventilator-associated pneumonia. Rev Bras TerIntensiva. 2012; 24 (4): 369-374. Doi: 10.1590/s0103-507x2012000400013. DOI: https://doi.org/10.1590/S0103-507X2012000400013

NOBAHAR, M. et al. Effects of hydrogen peroxide mouthwash on preventing ventilator-associated pneumonia in patients admitted to the intensive care unit. The Brazilian journal of infectious diseases. v. 20, n. 5, p. 444 - 450.2016. doi:10.1016/j.bjid.2016.06.005 DOI: https://doi.org/10.1016/j.bjid.2016.06.005

PRICE, R; MACLENNAN, G; GLEN, J. Selective digestive or oropharyngeal decontamination and topical oropharyngealchlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis. BMJ 2014; 348: g2197. DOI: https://doi.org/10.1136/bmj.g2197

SEDWICK, MB. et. al. Using evidence-based practice to prevent ventilator-associated pneumonia. Crit Care Nurse [Internet]. 2012; 32(4):41-51. Disponível em: http://doi.org/10.4037/ccn2012964. DOI: https://doi.org/10.4037/ccn2012964

SEGUIN, P. et al. Effect of oropharyngealpovidone-iodine preventive oral care on ventilator-associated pneumonia in severely brain-injured or cerebral hemorrhage patients: a multicenter, randomized controlled trial. Critical care medicine. v. 42, n. 1, p. 1 - 8. 2014. doi:10.1097/CCM.0b013e3182a2770f DOI: https://doi.org/10.1097/CCM.0b013e3182a2770f

SHI, Z. et al. Oral hygiene regimes for mechanically ventilated patients that use chlorhexidine reduce ventilator associated pneumonia. Cochrane Database Syst Rev 2013; Issue 8. Art. No.: CD008367. DOI: 10.1002/14651858.CD008367.pub2. DOI: https://doi.org/10.1002/14651858.CD008367.pub2

TINGTING, Z. et. al. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia.Cochrane Database Syst Rev 2020 Dec 24;12(12):CD008367.Doi: 10.1002/14651858.CD008367.pub4. DOI: https://doi.org/10.1002/14651858.CD008367.pub4

TUON, F. et. al. Prospective, randomised, controlled study evaluating early modification of oral microbiota following admission to the intensive care unit and oral hygiene with chlorhexidine. Randomized Controlled Trial.J Glob Antimicrob Resist. 2017 Mar; 8:159-163. Doi: 10.1016/j.jgar.2016.12.007. Epub 2017 Feb 20.

VIDAL, C. F. L. et al. Impact of oral hygiene involving toothbrushing versus chlorhexidine in the prevention of ventilator-associated pneumonia: a randomized study. BMC infectious diseases. v. 17, n. 1, p. 112. 2017, doi:10.1186/s12879-017-2188-0 DOI: https://doi.org/10.1186/s12879-017-2188-0

VIEIRA, P.C; OLIVEIRA, R.B; SILVA MENDONÇA, T.M. Should oral chlorhexidine remain inventilator-associated pneumonia prevention bundles?.2020. Medicina Intensiva 46(2022) 259---268. DOI: https://doi.org/10.1016/j.medin.2020.09.009

VILELA, M.C. et. al. Oral care and nosocomial pneumonia: a systematic review. Einstein. 2015;13(2):290-6. DOI: 10.1590/S1679-45082015RW2980. DOI: https://doi.org/10.1590/S1679-45082015RW2980

VILLAR, C. et. al. Effectiveness of Intraoral Chlorhexidine Protocols in the Prevention of Ventilator-Associated Pneumonia: Meta-Analysis and Systematic Review. RESPIRATORY CARE Paper in Press.Published on August 09, 2016 as DOI: 10.4187/respcare.04610. DOI: https://doi.org/10.4187/respcare.04610

ZAND, F. et al. The effects of oral rinse with 0.2% and 2% chlorhexidine on oropharyngeal colonization and ventilator associated pneumonia in adults' intensive care units. Journal of critical care. v. 40, p. 318 - 322. 2017. doi:10.1016/j.jcrc.2017.02.029 DOI: https://doi.org/10.1016/j.jcrc.2017.02.029

Published

2024-01-31

How to Cite

Gomes, G. da C., Mendes, S. P. L., & Pains, M. B. (2024). CLOREXIDINA E PREVENÇÃO DE PNEUMONIA ASSOCIADA À VENTILAÇÃO MECÂNICA: REVISÃO INTEGRATIVA SOBRE INCIDÊNCIA DE PAV E MORTALIDADE. Revista Contemporânea, 4(1), 4425–4444. https://doi.org/10.56083/RCV4N1-240

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