Vol 23, No 2 (2020)
Research paper
Published online: 2020-07-10

open access

Page views 1828
Article views/downloads 3861
Get Citation

Connect on Social Media

Connect on Social Media

Normal ranges of renal function parameters for 99mTc-EC renal scintigraphy

Agata Danilczuk1, Anna Nocun1, Beata Chrapko1
Pubmed: 33007090
Nucl. Med. Rev 2020;23(2):53-57.

Abstract

BACKGROUND: Dynamic renal scintigraphy remains the recognized method for evaluation of kidney function and perfusion.
Although there is an extensive body of knowledge about the use of technetium-99m-mercaptoacetyltriglycine (99mTc-MAG3),
much less has been written about renal technetium-99m-ethylenedicysteine (99mTc-EC) scintigraphy.
The aim of this study was to determine the normal value of renal function parameters in 99mTc-EC dynamic renal scintigraphy:
Tmax and T1/2. The effects of age, left or right side in the retroperitoneal space, and sex on those parameters were examined.
MATERIAL AND METHODS: The research was conducted on 123 patients (F/M: 70/53; aged 2–71; averaging 14.8 years of
age) with at least one normal kidney. A total of 194 healthy kidneys were examined, including pediatric kidneys.
RESULTS: According to this study, the normal value of Tmax is 2.85 min (± 1.16) and T1/2 is 8.7 min (± 3.61). Values calculated
for pediatric studies are Tmax is 2.81 (± 1.16) and T1/2 is 8.63 (± 3.71).
CONCLUSIONS: The normal value of secretory and excretory renal function parameters was calculated. Although the value
is slightly lower for children, this is not statistically significant, as globally there are no differences between the kidney-location
sides and sexes for any parameter.

Article available in PDF format

View PDF Download PDF file

References

  1. Mititelu R, Bratu O. Radionuclide Imaging. An Update on the Use of Dynamic Renal Scintigraphy. Medicina Moderna - Modern Medicine. 2017; 24(4): 199–203.
  2. Taylor AT. Radionuclides in nephrourology, Part 2: pitfalls and diagnostic applications. J Nucl Med. 2014; 55(5): 786–798.
  3. Keramida G, James JM, Prescott MC, et al. Pitfalls and Limitations of Radionuclide Renal Imaging in Adults. Semin Nucl Med. 2015; 45(5): 428–439.
  4. Moran JK. Technetium-99m-EC and other potential new agents in renal nuclear medicine. Semin Nucl Med. 1999; 29(2): 91–101.
  5. Kabasakal L, Turoğlu HT, Onsel C, et al. Clinical comparison of technetium-99m-EC, technetium-99m-MAG3 and iodine-131-OIH in renal disorders. J Nucl Med. 1995; 36(2): 224–228.
  6. Ell PJ, Gambhir SS. Nuclear Medicine in Clinical Diagnosis and Treatment, 3rd ed. AJNR Am J Neuroradiol. 2006; 27: 464–465.
  7. European Nuclear Medicine Guide. https://www.nucmed-guide.app/#!/chapter/312 (2.01.2019).
  8. Taylor AT. Radionuclides in nephrourology, part 1: Radiopharmaceuticals, quality control, and quantitative indices. J Nucl Med. 2014; 55(4): 608–615.
  9. Gordon I, Piepsz A, Sixt R. Guidelines for standard and diuretic renogram in children. Eur J Nucl Med Mol Imaging. 2011; 38(6): 1175–1188.
  10. Kabasakal L, Atay S, Vural VA, et al. Evaluation of technetium-99m-ethylenedicysteine in renal disorders and determination of extraction ratio. J Nucl Med. 1995; 36(8): 1398–1403.
  11. Van Nerom CG, Bormans GM, De Roo MJ, et al. First experience in healthy volunteers with technetium-99m L,L-ethylenedicysteine, a new renal imaging agent. Eur J Nucl Med. 1993; 20(9): 738–746.
  12. Kibar M, Noyan A, Anarat A. 99Tcm-N,N-ethylenedicysteine scintigraphy in children with various renal disorders: a comparative study with 99Tcm-MAG3. Nucl Med Commun. 1997; 18(1): 44–52.
  13. Lever SZ, Lever JR. Technetium-99m Pharmaceuticals: Preparation and Quality Control in Nuclear Medicine. J Nucl Med. 2009; 50(5): 831–831.
  14. Prigent A, Cosgriff P, Gates GF, et al. Consensus report on quality control of quantitative measurements of renal function obtained from the renogram: International Consensus Committee from the Scientific Committee of Radionuclides in Nephrourology. Semin Nucl Med. 1999; 29(2): 146–159.
  15. Sohaib M, Rafique A, Saeed S, et al. A comparison of single plasma sample methods to estimate renal clearance using 99mTc-ethylenedicysteine and 99mTc-mercaptoacetyltriglycine. Clin Physiol Funct Imaging. 2013; 33(5): 353–358.
  16. Sabolić I, Asif AR, Budach WE, et al. Gender differences in kidney function. Pflugers Arch. 2007; 455(3): 397–429.
  17. Lin WY, Changlai SP, Kao CH. Normal ranges of renal physiological parameters for technetium-99m mercaptoacetyltriglycine and the influence of age and sex using a camera-based method. Urol Int. 1998; 60(1): 11–16.
  18. Jung HS, Chung YAn, Kim EN, et al. Influence of hydration status in normal subjects: fractional analysis of parameters of Tc-99m DTPA and Tc-99m MAG3 renography. Ann Nucl Med. 2005; 19(1): 1–7.
  19. Durand E, Blaufox MD, Britton KE, et al. International Scientific Committee of Radionuclides in Nephrourology (ISCORN). International Scientific Committee of Radionuclides in Nephrourology (ISCORN) consensus on renal transit time measurements. Semin Nucl Med. 2008; 38(1): 82–102.
  20. Barde MP, Barde PJ. What to use to express the variability of data: Standard deviation or standard error of mean? Perspect Clin Res. 2012; 3(3): 113–116.