Research Article
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Year 2023, Volume: 3 Issue: 2, 62 - 66, 29.04.2023

Serap Çetiner Özgür Okuturlar

https://doi.org/10.56016/dahudermj.1260289

Abstract

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" İnsülin direncinde trigliserit ve hemogram indeksleri arasında bir ilişki var mı?" başlıklı bu makaleyi sunduk. Diyabeti olmayan obez ve insülin direnci yüksek olanlarda trigliserid düzeyleri yüksek bulundu. İnsülin direncinde trigliserit düzeyinin hematokrit, platelet lenfosit oranı ve ferritin ile anlamlı korelasyonu, bu parametrelerin aterosklerotik süreçte önemli olacağı düşüncesindeyiz.

References

  • Ndisang JF, Rastogi S, Vannacci A. Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2015. J Diabetes Res. 2015;2015:234135. doi: 10.1155/2015/234135. Epub 2015 Jul 28.
  • Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007 Jul 18;298(3):299-308. doi: 10.1001/jama.298.3.299.
  • Lahoz C, Mostaza JM. Familial hypertriglyceridemia/polygenic hypertrigliceridemia. Clin Investig Arterioscler. 2021 May;33 Suppl 2:37-42. English, Spanish. doi: 10.1016/j.arteri.2020.12.014.
  • Barbieri M, Ragno E, Benvenuti E, Zito GA, Corsi A, Ferrucci L, Paolisso G. New aspects of the insulin resistance syndrome: impact on haematological parameters. Diabetologia. 2001 Oct;44(10):1232-7. doi: 10.1007/s001250100634.
  • Fan X, Liu EY, Freudenreich O, Park JH, Liu D, Wang J, Yi Z, Goff D, Henderson DC. Higher white blood cell counts are associated with an increased risk for metabolic syndrome and more severe psychopathology in non-diabetic patients with schizophrenia. Schizophr Res. 2010 May;118(1-3):211-7. doi: 10.1016/j.schres.2010.02.1028.
  • Phillips AC, Carroll D, Gale CR, Drayson M, Thomas GN, Batty GD. Lymphocyte sub-population cell counts are associated with the metabolic syndrome and its components in the Vietnam Experience Study. Atherosclerosis. 2010 Nov;213(1):294-8. doi: 10.1016/j.atherosclerosis.2010.08.047.
  • Moan A, Nordby G, Os I, Birkeland KI, Kjeldsen SE. Relationship between hemorrheologic factors and insulin sensitivity in healthy young men. Metabolism. 1994 Apr;43(4):423-7. doi: 10.1016/0026-0495(94)90070-1. Erratum in: Metabolism 1994 Jul;43(7):929.
  • Fernández-Real JM, Peñarroja G, Castro A, García-Bragado F, Hernández-Aguado I, Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function. Diabetes. 2002 Apr;51(4):1000-4. doi: 10.2337/diabetes.51.4.1000.
  • Luque-Ramírez M, Alvarez-Blasco F, Botella-Carretero JI, Sanchón R, San Millán JL, Escobar-Morreale HF. Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses. Diabetes Care. 2007 Sep;30(9):2309-13. doi: 10.2337/dc07-0642.
  • Wu HC, Lee LC, Wang WJ. Plasmapheresis for hypertriglyceridemia: The association between blood viscosity and triglyceride clearance rate. J Clin Lab Anal. 2019 Feb;33(2):e22688. doi: 10.1002/jcla.22688.
  • Kim HS, Jung J, Dong SH, Kim SH, Jung SY, Yeo SG. Association Between High Neutrophil to Lymphocyte Ratio and Delayed Recovery From Bell's Palsy. Clin Exp Otorhinolaryngol. 2019 Aug;12(3):261-266. doi: 10.21053/ceo.2018.01018.
  • Angkananard T, Anothaisintawee T, McEvoy M, Attia J, Thakkinstian A. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018 Nov 11;2018:2703518. doi: 10.1155/2018/2703518.
  • Mochimaru T, Ueda S, Suzuki Y, Asano K, Fukunaga K. Neutrophil-to-lymphocyte ratio as a novel independent predictor of severe exacerbation in patients with asthma. Ann Allergy Asthma Immunol. 2019 Mar;122(3):337-339.e1. doi: 10.1016/j.anai.2018.11.029.
  • Renaud S, Seitlinger J, St-Pierre D, Garfinkle R, Al Lawati Y, Guerrera F, Ruffini E, Falcoz PE, Massard G, Ferri L, Spicer J. Prognostic value of neutrophil to lymphocyte ratio in lung metastasectomy for colorectal cancer. Eur J Cardiothorac Surg. 2019 May 1;55(5):948-955. doi: 10.1093/ejcts/ezy388.
  • Hasselbalch IC, Søndergaard HB, Koch-Henriksen N, Olsson A, Ullum H, Sellebjerg F, Oturai AB. The neutrophil-to-lymphocyte ratio is associated with multiple sclerosis. Mult Scler J Exp Transl Clin. 2018 Nov 28;4(4):2055217318813183. doi: 10.1177/2055217318813183.
  • Cho Y, Kim JW, Yoon HI, Lee CG, Keum KC, Lee IJ. The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Head and Neck Cancer Patients Treated with Radiotherapy. J Clin Med. 2018 Dec 3;7(12):512. doi: 10.3390/jcm7120512.
  • Elbistanli MS, Koçak HE, Acipayam H, Yiğider AP, Keskin M, Kayhan FT. The Predictive Value of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio for the Effusion Viscosity in Otitis Media With Chronic Effusion. J Craniofac Surg. 2017 May;28(3):e244-e247. doi: 10.1097/SCS.0000000000003452.
  • Kara A, Guven M, Yilmaz MS, Demir D, Elden H. Are neutrophil, platelet and eosinophil-to-lymphocyte ratio and red blood cell distribution width can be used for nasal polyposis? Eur Arch Otorhinolaryngol. 2018 Feb;275(2):409-413. doi: 10.1007/s00405-017-4821-3.
  • Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases. Ann Lab Med. 2019 Jul;39(4):345-357. doi: 10.3343/alm.2019.39.4.345.
  • Bozzini C, Girelli D, Olivieri O, Martinelli N, Bassi A, De Matteis G, Tenuti I, Lotto V, Friso S, Pizzolo F, Corrocher R. Prevalence of body iron excess in the metabolic syndrome. Diabetes Care. 2005 Aug;28(8):2061-3. doi: 10.2337/diacare.28.8.2061.
  • Sun L, Franco OH, Hu FB, Cai L, Yu Z, Li H, Ye X, Qi Q, Wang J, Pan A, Liu Y, Lin X. Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese. J Clin Endocrinol Metab. 2008 Dec;93(12):4690-6. doi: 10.1210/jc.2008-1159.
  • Trombini P, Piperno A. Ferritin, metabolic syndrome and NAFLD: elective attractions and dangerous liaisons. J Hepatol. 2007 Apr;46(4):549-52. doi: 10.1016/j.jhep.2007.01.004.
  • Kim HC, Kim DJ, Huh KB. Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome. Atherosclerosis. 2009 Jun;204(2):521-5. doi: 10.1016/j.atherosclerosis.2008.09.012.
  • Valenti L, Fracanzani AL, Dongiovanni P, Bugianesi E, Marchesini G, Manzini P, Vanni E, Fargion S. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol. 2007 Jun;102(6):1251-8. doi: 10.1111/j.1572-0241.2007.01192.x.
  • Reiner Ž. Statins in the primary prevention of cardiovascular disease. Nat Rev Cardiol. 2013 Aug;10(8):453-64. doi: 10.1038/nrcardio.2013.80.
  • Graham I, Cooney MT, Bradley D, Dudina A, Reiner Z. Dyslipidemias in the prevention of cardiovascular disease: risks and causality. Curr Cardiol Rep. 2012 Dec;14(6):709-20. doi: 10.1007/s11886-012-0313-7.
  • Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Borén J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P, Masana L, Nordestgaard BG, Ray KK, Reiner Z, Taskinen MR, Tokgözoglu L, Tybjærg-Hansen A, Watts GF; European Atherosclerosis Society Consensus Panel. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J. 2011 Jun;32(11):1345-61. doi: 10.1093/eurheartj/ehr112.
  • Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H. Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T., … Kathiresan, S. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature genetics, 2013 45(11), 1345–1352. https://doi.org/10.1038/ng.2795
  • Ma H, Xu C, Xu L, Yu C, Miao M, Li Y. Independent association of HbA1c and nonalcoholic fatty liver disease in an elderly Chinese population. BMC Gastroenterol. 2013 Jan 7;13:3. doi: 10.1186/1471-230X-13-3. PMID: 23294935; PMCID: PMC3543719.
  • Sung KC, Kim BS, Cho YK, Park DI, Woo S, Kim S, Wild SH, Byrne CD. Predicting incident fatty liver using simple cardio-metabolic risk factors at baseline. BMC Gastroenterol. 2012 Jul 6;12:84. doi: 10.1186/1471-230X-12-84.

Is there any relationship between triglyceride and hemogram indicesin insulin resistance ?

Year 2023, Volume: 3 Issue: 2, 62 - 66, 29.04.2023

Serap Çetiner Özgür Okuturlar

https://doi.org/10.56016/dahudermj.1260289

Abstract

Objective: We aimed to evaluate triglyceride (TG) level correlation with hemogram and biochemical parameters in non-diabetic but insulin-resistant and non-insulin-resistant obese patients.
Methods: Patients with diabetes, neurological, cardiac, and rheumatological diseases were excluded from the study. Statistical analysis was performed by recording the patients' hemogram and all biochemical parameters. The patients were divided into two groups. Patients with a HOMA-IR level below 2.7 in group 1 and patients with a HOMA-IR level above 2.7 in group 2.
Results: 70 patients were selected for our study. Twenty-four were assigned as those without insulin resistance and were named Group 1, and 46 of these patients were assigned as those with insulin resistance and were named Group 2. TG level was found to be lower in Group 1(80.05+32.17) compared to Group 2 (176.67+16.21) (p = 0.0001).
There was no significant correlation between TG level and hemogram parameters in group 1. In Group 2, TG level and hematocrit (r = 0.475; p = 0.001) showed a significant positive correlation, while platelet lymphocyte ratio (r = 0.474; p = 0.001) showed a significant negative correlation. In Group 2, TG and ferritin (r = 0.421; p = 0.004) showed a significant positive correlation.
Conclusion: In obese patients without diabetes, triglyceride levels were high in those with high insulin resistance. The significant correlation of triglyceride level with hct, PLR, and ferritin in insulin resistance reveals the importance of these parameters in the atherosclerotic process.

Keywords

Insulin Resistance Triglycerides Hematocrit Lymphocytes Blood Platelets Ferritin

References

  • Ndisang JF, Rastogi S, Vannacci A. Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2015. J Diabetes Res. 2015;2015:234135. doi: 10.1155/2015/234135. Epub 2015 Jul 28.
  • Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007 Jul 18;298(3):299-308. doi: 10.1001/jama.298.3.299.
  • Lahoz C, Mostaza JM. Familial hypertriglyceridemia/polygenic hypertrigliceridemia. Clin Investig Arterioscler. 2021 May;33 Suppl 2:37-42. English, Spanish. doi: 10.1016/j.arteri.2020.12.014.
  • Barbieri M, Ragno E, Benvenuti E, Zito GA, Corsi A, Ferrucci L, Paolisso G. New aspects of the insulin resistance syndrome: impact on haematological parameters. Diabetologia. 2001 Oct;44(10):1232-7. doi: 10.1007/s001250100634.
  • Fan X, Liu EY, Freudenreich O, Park JH, Liu D, Wang J, Yi Z, Goff D, Henderson DC. Higher white blood cell counts are associated with an increased risk for metabolic syndrome and more severe psychopathology in non-diabetic patients with schizophrenia. Schizophr Res. 2010 May;118(1-3):211-7. doi: 10.1016/j.schres.2010.02.1028.
  • Phillips AC, Carroll D, Gale CR, Drayson M, Thomas GN, Batty GD. Lymphocyte sub-population cell counts are associated with the metabolic syndrome and its components in the Vietnam Experience Study. Atherosclerosis. 2010 Nov;213(1):294-8. doi: 10.1016/j.atherosclerosis.2010.08.047.
  • Moan A, Nordby G, Os I, Birkeland KI, Kjeldsen SE. Relationship between hemorrheologic factors and insulin sensitivity in healthy young men. Metabolism. 1994 Apr;43(4):423-7. doi: 10.1016/0026-0495(94)90070-1. Erratum in: Metabolism 1994 Jul;43(7):929.
  • Fernández-Real JM, Peñarroja G, Castro A, García-Bragado F, Hernández-Aguado I, Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function. Diabetes. 2002 Apr;51(4):1000-4. doi: 10.2337/diabetes.51.4.1000.
  • Luque-Ramírez M, Alvarez-Blasco F, Botella-Carretero JI, Sanchón R, San Millán JL, Escobar-Morreale HF. Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses. Diabetes Care. 2007 Sep;30(9):2309-13. doi: 10.2337/dc07-0642.
  • Wu HC, Lee LC, Wang WJ. Plasmapheresis for hypertriglyceridemia: The association between blood viscosity and triglyceride clearance rate. J Clin Lab Anal. 2019 Feb;33(2):e22688. doi: 10.1002/jcla.22688.
  • Kim HS, Jung J, Dong SH, Kim SH, Jung SY, Yeo SG. Association Between High Neutrophil to Lymphocyte Ratio and Delayed Recovery From Bell's Palsy. Clin Exp Otorhinolaryngol. 2019 Aug;12(3):261-266. doi: 10.21053/ceo.2018.01018.
  • Angkananard T, Anothaisintawee T, McEvoy M, Attia J, Thakkinstian A. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018 Nov 11;2018:2703518. doi: 10.1155/2018/2703518.
  • Mochimaru T, Ueda S, Suzuki Y, Asano K, Fukunaga K. Neutrophil-to-lymphocyte ratio as a novel independent predictor of severe exacerbation in patients with asthma. Ann Allergy Asthma Immunol. 2019 Mar;122(3):337-339.e1. doi: 10.1016/j.anai.2018.11.029.
  • Renaud S, Seitlinger J, St-Pierre D, Garfinkle R, Al Lawati Y, Guerrera F, Ruffini E, Falcoz PE, Massard G, Ferri L, Spicer J. Prognostic value of neutrophil to lymphocyte ratio in lung metastasectomy for colorectal cancer. Eur J Cardiothorac Surg. 2019 May 1;55(5):948-955. doi: 10.1093/ejcts/ezy388.
  • Hasselbalch IC, Søndergaard HB, Koch-Henriksen N, Olsson A, Ullum H, Sellebjerg F, Oturai AB. The neutrophil-to-lymphocyte ratio is associated with multiple sclerosis. Mult Scler J Exp Transl Clin. 2018 Nov 28;4(4):2055217318813183. doi: 10.1177/2055217318813183.
  • Cho Y, Kim JW, Yoon HI, Lee CG, Keum KC, Lee IJ. The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Head and Neck Cancer Patients Treated with Radiotherapy. J Clin Med. 2018 Dec 3;7(12):512. doi: 10.3390/jcm7120512.
  • Elbistanli MS, Koçak HE, Acipayam H, Yiğider AP, Keskin M, Kayhan FT. The Predictive Value of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio for the Effusion Viscosity in Otitis Media With Chronic Effusion. J Craniofac Surg. 2017 May;28(3):e244-e247. doi: 10.1097/SCS.0000000000003452.
  • Kara A, Guven M, Yilmaz MS, Demir D, Elden H. Are neutrophil, platelet and eosinophil-to-lymphocyte ratio and red blood cell distribution width can be used for nasal polyposis? Eur Arch Otorhinolaryngol. 2018 Feb;275(2):409-413. doi: 10.1007/s00405-017-4821-3.
  • Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases. Ann Lab Med. 2019 Jul;39(4):345-357. doi: 10.3343/alm.2019.39.4.345.
  • Bozzini C, Girelli D, Olivieri O, Martinelli N, Bassi A, De Matteis G, Tenuti I, Lotto V, Friso S, Pizzolo F, Corrocher R. Prevalence of body iron excess in the metabolic syndrome. Diabetes Care. 2005 Aug;28(8):2061-3. doi: 10.2337/diacare.28.8.2061.
  • Sun L, Franco OH, Hu FB, Cai L, Yu Z, Li H, Ye X, Qi Q, Wang J, Pan A, Liu Y, Lin X. Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese. J Clin Endocrinol Metab. 2008 Dec;93(12):4690-6. doi: 10.1210/jc.2008-1159.
  • Trombini P, Piperno A. Ferritin, metabolic syndrome and NAFLD: elective attractions and dangerous liaisons. J Hepatol. 2007 Apr;46(4):549-52. doi: 10.1016/j.jhep.2007.01.004.
  • Kim HC, Kim DJ, Huh KB. Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome. Atherosclerosis. 2009 Jun;204(2):521-5. doi: 10.1016/j.atherosclerosis.2008.09.012.
  • Valenti L, Fracanzani AL, Dongiovanni P, Bugianesi E, Marchesini G, Manzini P, Vanni E, Fargion S. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol. 2007 Jun;102(6):1251-8. doi: 10.1111/j.1572-0241.2007.01192.x.
  • Reiner Ž. Statins in the primary prevention of cardiovascular disease. Nat Rev Cardiol. 2013 Aug;10(8):453-64. doi: 10.1038/nrcardio.2013.80.
  • Graham I, Cooney MT, Bradley D, Dudina A, Reiner Z. Dyslipidemias in the prevention of cardiovascular disease: risks and causality. Curr Cardiol Rep. 2012 Dec;14(6):709-20. doi: 10.1007/s11886-012-0313-7.
  • Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Borén J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P, Masana L, Nordestgaard BG, Ray KK, Reiner Z, Taskinen MR, Tokgözoglu L, Tybjærg-Hansen A, Watts GF; European Atherosclerosis Society Consensus Panel. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J. 2011 Jun;32(11):1345-61. doi: 10.1093/eurheartj/ehr112.
  • Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H. Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T., … Kathiresan, S. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature genetics, 2013 45(11), 1345–1352. https://doi.org/10.1038/ng.2795
  • Ma H, Xu C, Xu L, Yu C, Miao M, Li Y. Independent association of HbA1c and nonalcoholic fatty liver disease in an elderly Chinese population. BMC Gastroenterol. 2013 Jan 7;13:3. doi: 10.1186/1471-230X-13-3. PMID: 23294935; PMCID: PMC3543719.
  • Sung KC, Kim BS, Cho YK, Park DI, Woo S, Kim S, Wild SH, Byrne CD. Predicting incident fatty liver using simple cardio-metabolic risk factors at baseline. BMC Gastroenterol. 2012 Jul 6;12:84. doi: 10.1186/1471-230X-12-84.
There are 30 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Research Articles
Authors

Serap Çetiner 0000-0002-0846-5908

Özgür Okuturlar 0000-0003-2297-7464

Early Pub Date April 28, 2023
Publication Date April 29, 2023
Submission Date March 5, 2023
Published in Issue Year 2023 Volume: 3 Issue: 2

Cite

EndNote Çetiner S, Okuturlar Ö (April 1, 2023) Is there any relationship between triglyceride and hemogram indicesin insulin resistance ?. DAHUDER Medical Journal 3 2 62–66.
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