Association of human leukocyte antigen DRB1 polymorphism and tuberculosis: a meta-analysis
METHODS: Pooled odds ratios (OR) with 95% confidence intervals (CIs) were used to evaluate the strength of the association between HLA-DRB1 alleles and risk of TB. The χ2-based Q-test and I 2 statistics were calculated to examine heterogeneity. Egger's test was performed for the assessment of publication bias. Subgroup analysis was performed based on ethnicity and genotyping methods.
RESULTS: A total of 19 case-control studies with 16 alleles (HLA-DRB1*01–HLA-DRB1*16) were included in this meta-analysis. No significant publication bias was detected among these studies. The HLA-DRB1*03 (OR 0.77, 95%CI 0.64–0.93, P = 0.0057) showed a protective effect, while HLA-DRB1*04 (OR 1.24, 95%CI 1.00–1.55, P = 0.0494), HLA-DRB1*08 (OR 1.45, 95%CI 1.14–1.86, P = 0.0030) and HLA-DRB1*16 (OR 1.39, 95%CI 1.04–1.87, P = 0.0269) were significantly associated with increased TB occurrence. Subgroup analysis showed that both ethnicity and genotyping method affected the association between HLA-DRB1*03, HLA-DRB1*04 and HLA-DRB1*08 alleles and TB occurrence.
CONCLUSION: These results reinforce the importance of HLA-DRB1 alleles in the development of infectious diseases.
Keywords: TB; gene polymorphism; human leukocyte antigen DRB1 (HLA-DRB1); meta-analysis
Document Type: Research Article
Affiliations: Second Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University Medical School, Shaanxi, China
Publication date: 01 January 2016
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