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Home / The International Journal of Tuberculosis and Lung Disease, Volume 17, Number 5

Human toll-like receptor 1 T1805G polymorphism and susceptibility to pulmonary tuberculosis in northern Spain [Short communication]

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Toll-like receptors (TLRs) are key sensors of mycobacterial infections and play a crucial role in the initiation and coordination of the antimycobacterial innate immune response. T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but contradictory results among different populations have been reported. Our objective was to study this SNP in a genetically homogeneous population to evaluate its role in conferring susceptibility or resistance to PTB. In our population, the 1805G allele and the GG genotype (OR 2.04, 95%CI 1.26–3.31) influence susceptibility to PTB, in contrast with data observed in other populations.

Keywords: TLR1; genotype; polymorphism; pulmonary tuberculosis; susceptibility

Document Type: Research Article

Affiliations: 1: Immunology Service, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain 2: Pneumology Service, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain 3: Cantabria Regional Blood Centre, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain 4: Infectious Diseases Unit, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain

Publication date: 01 May 2013

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

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