Measurement of Biological Cell Deformability
Sota Iinuma, Shigehiro Hashimoto
Proceedings of the 15th International Multi-Conference on Complexity, Informatics and Cybernetics: IMCIC 2024, pp. 5-8 (2024); https://doi.org/10.54808/IMCIC2024.01.5
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The 15th International Multi-Conference on Complexity, Informatics and Cybernetics: IMCIC 2024
Virtual Conference March 26 - 29, 2024 Proceedings of IMCIC 2024 ISSN: 2771-5914 (Print) ISBN (Volume): 978-1-950492-78-7 (Print) |
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Abstract
Cell shape changes depending on the surrounding environment: mechanical fields (gravitational and fluid forces), electric fields, magnetic fields, electrochemical interactions at interfaces, etc. Deformation responses to environmental stimuli represent cell properties and activities. Stimuli that cause deformation include mechanical fields, electric fields, and magnetic fields. By restricting cell movement in the flow path, cell deformation can be observed: the shape of the channel wall, gaps, etc. The deformability of a cell is related to its function. For example, red blood cells that are insufficiently deformable cannot pass through capillaries and continue to circulate in the blood circulation system. Cancer cells are thought to have different deformability from normal cells. Measuring the deformability of cells can be applied to disease diagnosis and cell selection. This paper reviews research on measuring the deformability of cells and provides an outlook for future research developments.
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