Open Access, Peer-reviewed
pISSN 2287-2434
eISSN 2287-447X
    J Korean Oncol Nurs. 2011 Feb;11(1):33-40. Korean.
    Published online Mar 14, 2011.
    https://doi.org/10.5388/jkon.2011.11.1.33
    © 2011 Korean Oncology Nursing Society
    Original Article

    Randomized Controlled Trial for Preventing Stomatitis and Discomfort among Acute Leukemic Patients

    Chi Eun Song,1 Hyang Sook So,2 Deok Ju,3 and Eun Jeong Kim4
      • 1Nurse, Chonnam National University Hwasun Hospital, Hwasun, Korea.
      • 2Professor, College of Nursing, Chonnam National University, Gwangju, Korea.
      • 3Head Nurse, Chonnam National University Hwasun Hospital, Hwasun, Korea.
      • 4Nurse, Chonnam National University Hwasun Hospital, Hwasun, Korea.
    • Address reprint requests to: So, Hyang Sook. College of Nursing, Chonnam National University, 5 Hak-dong, Dong-gu, Gwangju 501-746, Korea. Tel: 82-62-220-4352, Fax: 82-62-227-4009, Email: hsso@chonnam.ac.kr
    Received November 17, 2010; Accepted January 12, 2011.

    Abstract

    Purpose

    This study compared the effect of two oral care agents on preventing stomatitis and discomfort for acute leukemic patients.

    Methods

    A total of forty patients was enrolled and randomly assigned to sodium bicarbonate or chlorhexidine group. WHO oral toxicity scale was used for measuring stomatitis and Beck's subjective oral discomfort scale for evaluating oral comfort. Data was collected from August 2009 to February 2010. The data was analyzed using Chi-square test, Fisher's exact test, and Mann-Whitney test.

    Results

    Data analyzed was thirty five one. The incidence of stomatitis was 47.4%, 68.8% in sodium bicarbonate and chlohexidine group respectively. The onset of stomatitis was about the 10th and 9th day after chemotherapy initiation, and the duration was 8.0 and 8.67 day respectively. The severity of stomatitis was highest on the 21st day after chemotherapy initiation. There were no statistical differences in the status of stomatitis and the levels of oral comfort during treatment periods.

    Conclusion

    Nurses should routinely assess oral cavity and encourage patients to do oral care actively from second to third week after chemotherapy initiation. Also sodium bicarbonate agent can be recommended to for preventing stomatitis.

    Keywords
    Randomized Controlled Trial; Stomatitis

    Figures

    Fig. 1
    Status of oral comfort by treatment periods.

    Tables

    Table 1
    Homogeneity test for general and clinical characteristics of subjects

    Table 2
    Difference of oral mucositis over WHO grade 2 by periods between two groups.

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    MeSH Terms
    Chlorhexidine
    Humans
    Incidence
    Mouth
    Sodium Bicarbonate
    Stomatitis
    Metrics
    Share
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