ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Thermosensitive and biodegrdable dextran based microgels for target drug delivery
Abstract: Micro-/nano- thermosensitive microgels are paramount in Nanomedicine, as they support a multifunctional approach for diseases treatment (localization and simultaneous controlled drug delivery). A microgel particle with enhanced thermoresponsivity allows to controll the drug release via the temperature change of the environment sourrounding the particle. In this respect we have designed and characterized biodegradable, hydrophilic dextran-based microgel particles with thermoresponsive behaviour consisting in a volume phase transition, i.e. a particle volume reduction when the system is brought to physiological temperature. With this proposal we plan to study the dynamic behaviour of the solvent (water) strongly associated in the microgel particles around the volume phase transition using IRIS, a spectrometer we used successfully for several type of polymer based hydrogels.
Public release date: 25 May 2014
Principal Investigator: Professor Gaio Paradossi
Experimenter: Dr Shivkumar Ghugare
DOI: 10.5286/ISIS.E.24085974
ISIS Experiment Number: RB1110134
Part Number: 1 - IRIS
Date of Experiment: 17 May 2011
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Gaio Paradossi et al; (2011): Thermosensitive and biodegrdable dextran based microgels for target drug delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.24085974
