ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Characterisation of Hybrid Lipid-Polymer Nanoparticles
Abstract: Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination with contrast variation to determine the detailed molecular structure of the drug-containing hybrid lipid-polymer nanoparticles, as well as their component lipid vesicles and polymeric nanoparticles. SANS coupled with contrast variation will allow us to establish precisely how much lipid is required to reproducibly and reliably coat the various sized polymeric NPs without using so much lipid so that excess vesicles are present. The information gained from SANS will be important in optimising the hybrid lipid-polymer formulations.
Public release date: 18 February 2023
Principal Investigator: Professor Jayne Lawrence
Experimenter: Dr Yu Lu
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Alex Clout
Experimenter: Dr Alice Spadea
Experimenter: Miss Yixuan Yan
DOI: 10.5286/ISIS.E.RB1920448-1
Parent DOI: 10.5286/ISIS.E.RB1920448
ISIS Experiment Number: RB1920448
Part Number: 1
Date of Experiment: 14 February 2020
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jayne Lawrence et al; (2020): Characterisation of Hybrid Lipid-Polymer Nanoparticles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920448-1
