ISIS Neutron and Muon Source Data Journal

Interplay of apoptosis regulating Bcl-2 proteins at mitochondrial membranes upon oxidative stress

Abstract: Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). This pathway is a major regulator in cell death where pro- and anti-survival Bcl-2 proteins meet at the mitochondrial outer membrane and decide the fate of a cell. Treatment-resistant tumour cells often possess mitochondria which are enriched in the pro-survival Bcl-2 membrane protein which blocks any killing (anti-survival) protein like BAX. Based on recent NR studies we will now investigate how the killer Bax protein interacts with mitochondrial-like membranes upon oxidative stress and how it will be inhibited in the presence of pro-survival Bcl-2 protein there. Information about this key protein complex is essential to understand the regulation of the cell's fate: why do healthy cells survive, damaged cells get removed and cancer cells escape.

Public release date: 21 June 2022

Principal Investigator: Professor Gerhard Groebner
Experimenter: Dr Hanna Wacklin-Knecht
Local Contact: Dr Luke Clifton
Experimenter: Dr Jörgen Ådén

DOI: 10.5286/ISIS.E.RB1910323-1

Parent DOI: 10.5286/ISIS.E.RB1910323

ISIS Experiment Number: RB1910323

Part Number: 1

Date of Experiment: 11 June 2019

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Gerhard Groebner et al; (2019): Interplay of apoptosis regulating Bcl-2 proteins at mitochondrial membranes upon oxidative stress, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910323-1