ISIS Neutron and Muon Source Data Journal

Organization of mitochondrial membranes upon oxidative stress: Impact on apoptosis regulating protein-lipid interactions of Bcl-2 proteins

Abstract: Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a major regulator in mammalian cells death, where pro- and anti-survival Bcl-2 proteins meet at the mitochondrial outer membrane and tightly regulate the fate of a cell. Treatment-resistant tumour cells often possess mitochondria which are enriched in the pro-survival Bcl-2 membrane protein which blocks any apoptotic signals upon onset via oxidative stress. Our main aim is to generate by using neutron reflectometry fundamental knowledge about the membrane mediated function of the cell-death causing (anti-survival) Bax protein and its counterplayer, the pro-survival Bcl-2 membrane protein to regulate and execute apoptosis; information also useful for novel cancer strategies.

Public release date: 06 July 2021

Principal Investigator: Professor Gerhard Groebner
Local Contact: Dr Mario Campana
Experimenter: Mr Artur Dingeldein
Experimenter: Dr Jörgen Ådén
Experimenter: Dr Hanna Wacklin-Knecht
Experimenter: Dr Luke Clifton
Local Contact: Dr Arwel Hughes

DOI: 10.5286/ISIS.E.89604880

Parent DOI: 10.5286/ISIS.E.RB1720424

ISIS Experiment Number: RB1720424

Part Number: 2

Date of Experiment: 03 July 2018

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Gerhard Groebner et al; (2018): Organization of mitochondrial membranes upon oxidative stress: Impact on apoptosis regulating protein-lipid interactions of Bcl-2 proteins, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.89604880