ISIS Neutron and Muon Source Data Journal

Antiplasticizing effect of water in amorphous prilocaine

Abstract: In glassforming organic materials, the addition of water usually has a direct plasticizing effect, visible in a lowering of the glass-transition temperature Tg upon hydration of the material (the lower the Tg the higher the relative water content). We have observed an antiplasticizing effect in a small molecule, prilocaine, caused by the addition of water. This shift in Tg has been observed both with Differential Scanning Calorimetry experiments and Broadband Dielectric Spectroscopy. The microscopic hydrating mechanisms underlying the macroscopic antiplasticizing effect upon the addition of water to prilocaine are still unknown. Here we propose to investigate the hydration structure of prilocaine in solution using neutron diffraction coupled with both EPSR and Molecular dynamics simulations.

Public release date: 28 May 2020

Principal Investigator: Dr Luis Carlos Pardo-Soto
Local Contact: Dr Silvia Imberti
Experimenter: Ms Guadalupe Ruiz
Experimenter: Dr Sylvia McLain
Experimenter: Ms Nicola Steinke
Experimenter: Dr Silvina Cerveny
Experimenter: Dr Michela Romanini
Experimenter: Dr Jose Luis Tamarit
Experimenter: Dr Roberto Macovez

DOI: 10.5286/ISIS.E.86387911

Parent DOI: 10.5286/ISIS.E.RB1710284

ISIS Experiment Number: RB1710284

Part Number: 1

Date of Experiment: 25 May 2017

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Luis Carlos Pardo-Soto et al; (2017): Antiplasticizing effect of water in amorphous prilocaine, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.86387911