ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Relaxational and diffusive properties of oligomeric and fibrillar forms of alpha-synuclein
Abstract: Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates and are characterized by the misfolding of a specific protein or proteins, i. e. alpha-synuclein in Parkinson¿s disease, beta-amyloid in Alzheimer¿s disease and huntingtin in Huntington¿s disease. In vivo alpha-synuclein assemblies in several aggregated forms: oligomeric, prefibrillar and fibrillar. Even if these different forms can be produced in vitro, the nature of the proteic aggregates causing the neuronal death is still debated. We propose to use IRIS to characterize the relaxational and diffusive properties of alpha-synuclein at 293K, 323K and 363K in H2O and D2O solutions. The diffusive dynamics of fibrillar and soluble species of alpha-synuclein will be compared and investigated also in the presence of trehalose, a bioprotectant disaccharide.
Public release date: 27 July 2015
Principal Investigator: Professor Federica Migliardo
Experimenter: Professor Salvatore Magazu
Experimenter: Professor Ronald Melki
Experimenter: Professor Luc Bousset
DOI: 10.5286/ISIS.E.24089233
ISIS Experiment Number: RB1210067
Part Number: 1 - IRIS
Date of Experiment: 16 July 2012
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Federica Migliardo et al; (2012): Relaxational and diffusive properties of oligomeric and fibrillar forms of alpha-synuclein, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.24089233
